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Sex hormones differentially contribute to Parkinson disease in males: A multimodal biomarker study.
Bovenzi, Roberta; Sancesario, Giulia Maria; Conti, Matteo; Grillo, Piergiorgio; Cerroni, Rocco; Bissacco, Jacopo; Forti, Paolo; Giannella, Emilia; Pieri, Massimo; Minosse, Silvia; Ferrazzoli, Valentina; Pucci, Noemi; Laudazi, Mario; Floris, Roberto; Garaci, Francesco; Pierantozzi, Mariangela; Stefani, Alessandro; Mercuri, Nicola Biagio; Picchi, Eliseo; Di Giuliano, Francesca; Schirinzi, Tommaso.
Afiliación
  • Bovenzi R; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Sancesario GM; IRCCS Fondazione Santa Lucia, European Centre for Brain Research, Rome, Italy.
  • Conti M; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Grillo P; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Cerroni R; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Bissacco J; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Forti P; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Giannella E; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Pieri M; IRCCS Fondazione Santa Lucia, European Centre for Brain Research, Rome, Italy.
  • Minosse S; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Ferrazzoli V; Department of Clinical Biochemistry, Tor Vergata University Hospital, Rome, Italy.
  • Pucci N; Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Laudazi M; Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Floris R; Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Garaci F; Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Pierantozzi M; Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Stefani A; Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Mercuri NB; San Raffaele Cassino, Cassino, Italy.
  • Picchi E; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Di Giuliano F; Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Schirinzi T; Parkinson Centre Unit, Tor Vergata University Hospital, Rome, Italy.
Eur J Neurol ; 30(7): 1983-1990, 2023 07.
Article en En | MEDLINE | ID: mdl-36971787
BACKGROUND AND PURPOSE: Parkinson disease (PD) presents relevant sex-related differences in epidemiology, pathophysiology, and clinical features, with males being more vulnerable to the disease. Sex hormones might have a role, as the experimental models suggest; however, human-based evidence is scarce. Here, we integrated multimodal biomarkers to investigate the relationships between circulating sex hormones and clinical-pathological features in male PD patients. METHODS: A cohort of 63 male PD patients underwent comprehensive clinical evaluation of motor and nonmotor disturbances; measurement of estradiol, testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) blood levels; and cerebrospinal fluid (CSF) assay of total α-synuclein, amyloid-ß-42, amyloid-ß-40, total tau, and phosphorylated-181 tau levels. A subgroup of 47 PD patients underwent brain volumetry by 3-T magnetic resonance imaging for further correlations. A control group of 56 age-matched individuals was enrolled for comparative analyses. RESULTS: Male PD patients had higher estradiol and testosterone levels than controls. Estradiol had independent inverse associations with Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part 3 score and disease duration; it was also lower in nonfluctuating patients. Testosterone had inverse independent correlations with CSF α-synuclein and right globus pallidus volume. FSH and LH had age-dependent correlations with cognitive impairment and CSF amyloid-ß-42/amyloid-ß-40 ratio. CONCLUSIONS: The study suggested that sex hormones could differentially contribute to clinical-pathological features of PD in male patients. Whereas estradiol might have a protective role in motor impairment, testosterone might be involved in male vulnerability to PD neuropathology. Gonadotropins instead might mediate age-dependent phenomena of amyloidopathy and cognitive decline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido