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Preparation and biological evaluation of radio conjugated cephradine complex for infection imaging.
Zahoor, Rizwana; Munawar, Aisha; Abbas, Kiran; Shahid, Abubaker; Afza Gardner, Qurratulann; Ullah Khan, Irfan.
Afiliación
  • Zahoor R; Institute of Nuclear Medicine & Oncology (INMOL), New Campus Road, Lahore, Pakistan/Department of Chemistry, University of Engineering and Technology (UET), Lahore, Pakistan.
  • Munawar A; Department of Chemistry, University of Engineering and Technology (UET), Lahore, Pakistan.
  • Abbas K; Department of Chemistry, University of Engineering and Technology (UET), Lahore, Pakistan.
  • Shahid A; Institute of Nuclear Medicine & Oncology (INMOL), New Campus Road, Lahore, Pakistan.
  • Afza Gardner Q; School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore, Pakistan.
  • Ullah Khan I; Institute of Nuclear Medicine & Oncology (INMOL), New Campus Road, Lahore, Pakistan.
Pak J Pharm Sci ; 36(1): 181-189, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36967510
Antimicrobial resistance is a major challenge in the field and threat to human life. Many patients are suffering from cancer, infection and other diseases simultaneously. Therefore, early detection of infection can lead to treatment of these patients with an appropriate antibiotic. Hence, the development of a specific imaging molecule can increase the speed of infection analysis and thereby application of proper antibiotic. The present work involves the optimization of labelling conditions for an antibiotic of cephalosporin family, cephradine with technetium-99m (99mTc) and establishment of quality control tests. Labelling of cephradine was also determined by applying MALDI-TOF mass spectrometry. Evaluation of in vitro binding with S. aureus bacteria was carried out. Animal model was used to conduct in vivo binding studies. For this, infected animals were injected with the radiolabelled ligand and images were captured by Gamma camera, to observe target to non-target uptake of radiolabelled complex. Furthermore, we optimized various parameters to achieve best labelling efficacy and stability of cephradine. Our results show that cephradine can be used as potential infection imaging agent for advanced clinical care.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Cefradina Tipo de estudio: Screening_studies Límite: Animals / Humans Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Cefradina Tipo de estudio: Screening_studies Límite: Animals / Humans Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán