Your browser doesn't support javascript.
loading
Cuscuta chinensis flavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring.
Zhao, Qianhui; Liu, Ying; Wang, Xiao; Zhu, Yixuan; Jiao, Yulan; Bao, Yongzhan; Shi, Wanyu.
Afiliación
  • Zhao Q; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
  • Liu Y; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
  • Wang X; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
  • Zhu Y; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
  • Jiao Y; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China; Hebei Veterinary Biotenology Innovation Center, Baoding 071001, China; Ruipu (Baoding) Biological Pharmaceutical Co., Ltd., Baoding 071000, China.
  • Bao Y; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
  • Shi W; College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China; Hebei Veterinary Biotenology Innovation Center, Baoding 071001, China. Electronic address: shiwanyu2010@126.com.
Ecotoxicol Environ Saf ; 255: 114831, 2023 Apr 15.
Article en En | MEDLINE | ID: mdl-36966614
Bisphenol A (BPA) is a common environmental endocrine disruptor, and overexposure is a threat to male reproduction. Although studies have confirmed that BPA exposure causes a decrease in sperm quality in offspring, the dosage used, and the underlying mechanism is not clear. The purpose of this study is to investigate whether Cuscuta chinensis flavonoids (CCFs) can antagonize or alleviate BPA-induced reproductive injury by analyzing the processes associated with BPA's impairment of sperm quality. BPA and 40 mg/kg bw/day of CCFs were administered to the dams at gestation day (GD) 0.5-17.5. Testicles and serum of male mice are collected on postnatal day 56 (PND56), and spermatozoa are collected to detect relevant indicators. Our results showed that compared with the BPA group, CCFs could significantly increase the serum contents of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) in males at PND 56, as well as the transcription levels of estrogen receptor alpha (ERα), steroidogenic acute regulatory protein (StAR) and Cytochrome P450 family 11, subfamily A, and member 1 (CYP11A1). CCFs also significantly inhibit the production of reactive oxygen species (ROS), reduce oxidative stress, increase mitochondrial membrane potential, and reduce sperm apoptosis. It also has a certain regulatory effect on sperm telomere length and mitochondrial DNA copy number. These results suggest that CCFs can increase reproductive hormone and receptor levels in adult males by regulating the expression of oxidative stress correlated factors, and ultimately mitigate the negative effects of BPA on sperm quality in male mice.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuscuta Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuscuta Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos