Enhancing Oil Solubility of BCS Class II Drug Phenytoin Through Hydrophobic Ion Pairing to Enable High Drug Load in Injectable Nanoemulsion to Prevent Precipitation at Physiological pH With a Potential to Prevent Phlebitis.

Modi, Dimple; Jonnalagadda, Sriramakamal; Campbell, Gossett A; Dalwadi, Gautam

Modi, Dimple; Jonnalagadda, Sriramakamal; Campbell, Gossett A; Dalwadi, Gautam.

Afiliación

Modi D; GlaxoSmithKline, Pharmaceutical Research and Development, Medicinal Science & Technology, 1250 S. Collegeville Road, Collegeville, PA 19426, United States; Saint Joseph's University, Philadelphia, PA 19104, United States.
Jonnalagadda S; Saint Joseph's University, Philadelphia, PA 19104, United States.
Campbell GA; GlaxoSmithKline, Pharmaceutical Research and Development, Medicinal Science & Technology, 1250 S. Collegeville Road, Collegeville, PA 19426, United States.
Dalwadi G; GlaxoSmithKline, Pharmaceutical Research and Development, Medicinal Science & Technology, 1250 S. Collegeville Road, Collegeville, PA 19426, United States. Electronic address: gautam.x.dalwadi@gsk.com.

J Pharm Sci ; 112(9): 2427-2443, 2023 09.

Article en En | MEDLINE | ID: mdl-36958691

Asunto(s)

Aceite de Ricino; Fenitoína; Solubilidad; Emulsiones; Micelas; Concentración de Iones de Hidrógeno; Agua/química

Palabras clave

High drug loading; In vitro precipitation; Ion-pairing; Micellization; Nanoemulsion; Phenytoin; pH-solubility

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenitoína / Aceite de Ricino Tipo de estudio: Prognostic_studies Idioma: En Revista: J Pharm Sci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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