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Prognostic value of metabolic tumor volume of extranodal involvement in diffuse large B cell lymphoma.
Oiwa, Kana; Fujita, Kei; Lee, Shin; Morishita, Tetsuji; Tsujikawa, Tetsuya; Negoro, Eiju; Hara, Takeshi; Tsurumi, Hisashi; Ueda, Takanori; Yamauchi, Takahiro.
Afiliación
  • Oiwa K; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
  • Fujita K; Department of Hematology and Oncology, Nagoya City University, Aichi, Japan.
  • Lee S; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
  • Morishita T; Department of Hematology and Oncology, Matsunami General Hospital, Dendai 185-1 Kasamatsu-Cho, Hashima-Gun, Gifu, 501-6062, Japan.
  • Tsujikawa T; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. leesin.581020@gmail.com.
  • Negoro E; Department of Hematology and Oncology, Matsunami General Hospital, Dendai 185-1 Kasamatsu-Cho, Hashima-Gun, Gifu, 501-6062, Japan. leesin.581020@gmail.com.
  • Hara T; Department of Internal Medicine, Matsunami General Hospital, Gifu, Japan.
  • Tsurumi H; Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Yoshida Konoe-Cho, Kyoto, Japan.
  • Ueda T; Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
  • Yamauchi T; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Ann Hematol ; 102(5): 1141-1148, 2023 May.
Article en En | MEDLINE | ID: mdl-36951966
Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact of the metabolic tumor burden (MTV) of extranodal sites using positron emission tomography has not been clarified. This study aimed to assess the impact of extranodal MTV on overall survival (OS). We retrospectively analyzed 145 newly diagnosed DLBCL patients and verified the prognostic impact of each extranodal and nodal MTV. Multivariate Cox hazards modelling using both extranodal and nodal MTV as covariables identified extranodal MTV as a significant factor for OS (hazard ratio [HR] 1.072, 95% confidence interval [CI] 1.019-1.129, P = 0.008), but not nodal MTV. Multivariate Cox modelling using restricted cubic splines demonstrated that the impact of total MTV depends on the MTV of extranodal sites, not of nodal sites. When both the number and MTV of extranodal involvements were used as covariables, extranodal MTV remained a significant predictor of OS (HR 1.070, 95%CI 1.017-1.127, P = 0.009), but the number of extranodal sites did not. Extranodal MTV potentially had a more significant role on prognosis than nodal MTV. When considering prognostic impacts, the MTV of extranodal involvement is significantly more important than the number.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Fluorodesoxiglucosa F18 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Fluorodesoxiglucosa F18 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania