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The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
Bornstein, Bavat; Watkins, Bridgette; Passini, Fabian S; Blecher, Ronen; Assaraf, Eran; Sui, Xiao Meng; Brumfeld, Vlad; Tsoory, Michael; Kröger, Stephan; Zelzer, Elazar.
Afiliación
  • Bornstein B; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
  • Watkins B; Department of Physiological Genomics, Biomedical Center, Ludwig-Maximilians-University, Planegg-Martinsried, Germany.
  • Passini FS; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
  • Blecher R; Orthopedic Department, Assuta Ashdod University Hospital, Ashdod, Israel, affiliated to Ben Gurion University of the Negev, Beer Sheba, Israel.
  • Assaraf E; Department of Orthopedic Surgery, Shamir Medical Center, Assaf HaRofeh Campus, Zeffifin, Israel, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Sui XM; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
  • Brumfeld V; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
  • Tsoory M; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
  • Kröger S; Department of Physiological Genomics, Biomedical Center, Ludwig-Maximilians-University, Planegg-Martinsried, Germany.
  • Zelzer E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Exp Physiol ; 109(1): 135-147, 2024 01.
Article en En | MEDLINE | ID: mdl-36951012
By translating mechanical forces into molecular signals, proprioceptive neurons provide the CNS with information on muscle length and tension, which is necessary to control posture and movement. However, the identities of the molecular players that mediate proprioceptive sensing are largely unknown. Here, we confirm the expression of the mechanosensitive ion channel ASIC2 in proprioceptive sensory neurons. By combining in vivo proprioception-related functional tests with ex vivo electrophysiological analyses of muscle spindles, we showed that mice lacking Asic2 display impairments in muscle spindle responses to stretch and motor coordination tasks. Finally, analysis of skeletons of Asic2 loss-of-function mice revealed a specific effect on spinal alignment. Overall, we identify ASIC2 as a key component in proprioceptive sensing and a regulator of spine alignment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propiocepción / Canales Iónicos Sensibles al Ácido Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propiocepción / Canales Iónicos Sensibles al Ácido Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido