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Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review.
Rajagopalan, Vahulabaranan; Venkataraman, Swethaa; Rajendran, Devi Sri; Vinoth Kumar, Vaidyanathan; Kumar, Vaithyanathan Vasanth; Rangasamy, Gayathri.
Afiliación
  • Rajagopalan V; Integrated Bioprocess Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India.
  • Venkataraman S; Integrated Bioprocess Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India.
  • Rajendran DS; Integrated Bioprocess Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India.
  • Vinoth Kumar V; Integrated Bioprocess Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India. Electronic address: vinothkv@srmist.edu.in.
  • Kumar VV; Department of Electronics and Communication Engineering, Hindustan Institute of Technology and Science, Chennai, India. Electronic address: vasanthtechnology@gmail.com.
  • Rangasamy G; School of Engineering, Lebanese American University, Byblos, Lebanon; University Centre for Research and Development & Department of Civil Engineering, Chandigarh University, Gharuan, Mohali, Punjab, 140413, India. Electronic address: granga1983@gmail.com.
Environ Res ; 227: 115724, 2023 06 15.
Article en En | MEDLINE | ID: mdl-36948285
Neurotoxic pesticides are a group of chemicals that pose a severe threat to both human health and the environment. These molecules are also known to accumulate in the food chain and persist in the environment, which can lead to long-term exposure and adverse effects on non-target organisms. The detrimental effects of these pesticides on neurotransmitter levels and function can lead to a range of neurological and behavioral symptoms, which are closely associated with neurodegenerative diseases. Hence, the accurate and reliable detection of these neurotoxic pesticides and associated neurotransmitters is essential for clinical applications, such as diagnosis and treatment. Over the past few decades, acetylcholinesterase (AchE) biosensors have emerged as a sensitive and reliable tool for the electrochemical detection of neurotoxic pesticides and acetylcholine. These biosensors can be tailored to utilize the high specificity and sensitivity of AchE, enabling the detection of these chemicals. Additionally, enzyme immobilization and the incorporation of nanoparticles have further improved the detection capabilities of these biosensors. AchE biosensors have shown tremendous potential in various fields, including environmental monitoring, clinical diagnosis, and pesticide residue analysis. This review summarizes the advancements in AchE biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine over the past two decades.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Residuos de Plaguicidas / Técnicas Biosensibles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Environ Res Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Residuos de Plaguicidas / Técnicas Biosensibles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Environ Res Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos