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Discovery of Nanomolar DCAF1 Small Molecule Ligands.
Li, Alice Shi Ming; Kimani, Serah; Wilson, Brian; Noureldin, Mahmoud; González-Álvarez, Héctor; Mamai, Ahmed; Hoffer, Laurent; Guilinger, John P; Zhang, Ying; von Rechenberg, Moritz; Disch, Jeremy S; Mulhern, Christopher J; Slakman, Belinda L; Cuozzo, John W; Dong, Aiping; Poda, Gennady; Mohammed, Mohammed; Saraon, Punit; Mittal, Manish; Modh, Pratik; Rathod, Vaibhavi; Patel, Bhashant; Ackloo, Suzanne; Santhakumar, Vijayaratnam; Szewczyk, Magdalena M; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H; Marcellus, Richard; Guié, Marie-Aude; Keefe, Anthony D; Brown, Peter J; Halabelian, Levon; Al-Awar, Rima; Vedadi, Masoud.
Afiliación
  • Li ASM; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Kimani S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Wilson B; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Noureldin M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • González-Álvarez H; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada.
  • Mamai A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Hoffer L; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Guilinger JP; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Zhang Y; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • von Rechenberg M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Disch JS; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Mulhern CJ; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Slakman BL; X-Chem Inc., Waltham, Massachusetts 02453, United States.
  • Cuozzo JW; X-Chem Inc., Waltham, Massachusetts 02453, United States.
  • Dong A; Relay Therapeutics, Cambridge, Massachusetts 02139, United States.
  • Poda G; Relay Therapeutics, Cambridge, Massachusetts 02139, United States.
  • Mohammed M; Relay Therapeutics, Cambridge, Massachusetts 02139, United States.
  • Saraon P; Relay Therapeutics, Cambridge, Massachusetts 02139, United States.
  • Mittal M; Relay Therapeutics, Cambridge, Massachusetts 02139, United States.
  • Modh P; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Rathod V; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Patel B; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
  • Ackloo S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Santhakumar V; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Szewczyk MM; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India.
  • Barsyte-Lovejoy D; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India.
  • Arrowsmith CH; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India.
  • Marcellus R; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, Gujarat 382213, India.
  • Guié MA; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Keefe AD; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Al-Awar R; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
J Med Chem ; 66(7): 5041-5060, 2023 04 13.
Article en En | MEDLINE | ID: mdl-36948210
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ubiquitina-Proteína Ligasas / Neoplasias Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ubiquitina-Proteína Ligasas / Neoplasias Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos