Black ginger extract and its active compound, 5,7-dimethoxyflavone, increase intestinal drug absorption via efflux drug transporter inhibitions.

Boonnop, Rattiporn; Meetam, Paranee; Siangjong, Lawan; Tuchinda, Patoomratana; Thongphasuk, Piyanut; Soodvilai, Sunhapas; Soodvilai, Sirima

Boonnop, Rattiporn; Meetam, Paranee; Siangjong, Lawan; Tuchinda, Patoomratana; Thongphasuk, Piyanut; Soodvilai, Sunhapas; Soodvilai, Sirima.

Afiliación

Boonnop R; Research Center of Transport Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Ratchathewi, Bangkok, 10400, Thailand.
Meetam P; Department of Biopharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand.
Siangjong L; Department of Biopharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand.
Tuchinda P; Excellent Center for Drug Discovery, Mahidol University, Ratchathewi, Bangkok, 10400, Thailand.
Thongphasuk P; Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathumthani, 12000, Thailand.
Soodvilai S; Research Center of Transport Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Ratchathewi, Bangkok, 10400, Thailand.
Soodvilai S; Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathumthani, 12000, Thailand. Electronic address: Sirima.s@rsu.ac.th.

Drug Metab Pharmacokinet ; 50: 100500, 2023 Jun.

Article en En | MEDLINE | ID: mdl-36948091

Asunto(s)

Absorción Intestinal; Proteínas de Neoplasias; Animales; Perros; Humanos; Preparaciones Farmacéuticas; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2/metabolismo; Células CACO-2; Proteínas de Neoplasias/metabolismo; Transporte Biológico; Subfamilia B de Transportador de Casetes de Unión a ATP/genética; Miembro 1 de la Subfamilia B de Casetes de Unión a ATP/metabolismo; Digoxina/farmacocinética

Palabras clave

Breast cancer resistance proteins (BCRP); Caco-2 cells; Dimethoxyflavone; Herb-drug interactions; Oral bioavailability; P-glycoprotein (P-gp)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Absorción Intestinal / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido

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