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Impact of Early-Life Factors on Risk for Schizophrenia and Bipolar Disorder.
Robinson, Natassia; Ploner, Alexander; Leone, Marica; Lichtenstein, Paul; Kendler, Kenneth S; Bergen, Sarah E.
Afiliación
  • Robinson N; Department of Medical Epidemiologiy and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Ploner A; Department of Medical Epidemiologiy and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Leone M; Department of Medical Epidemiologiy and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Lichtenstein P; Janssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden.
  • Kendler KS; Department of Medical Epidemiologiy and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Bergen SE; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Schizophr Bull ; 49(3): 768-777, 2023 05 03.
Article en En | MEDLINE | ID: mdl-36946500
BACKGROUND AND HYPOTHESIS: Schizophrenia (SCZ) and bipolar disorder (BD) have shared genetic risk and clinical symptoms, yet the extent to which environmental risk factors are shared is not well known. We aimed to examine the associations of early-life environmental exposures with the risk of SCZ and BD. STUDY DESIGN: We conducted a Swedish register-based nested case-control study using 4184 SCZ and 18 681 BD cases diagnosed 1988-2013, individually matched to 5 population-based controls by birth year, sex and birthplace. Conditional logistic regression was used to evaluate the risk of SCZ and BD by seasonality, severe prenatal infections, and perinatal factors. STUDY RESULTS: Seasonality had similar patterns of risk for both disorders: Higher risk for births November-December; lower risk April-June. Experiencing any perinatal factor was associated with a significantly higher risk of SCZ (incidence rate ratio [IRR] 1.19, 95%CI 1.11-1.63) and to a lesser extent BD (IRR 1.08, 95%CI 1.05-1.12). Prenatal infections were only associated with a greater risk of SCZ (IRR 1.30, 95%CI 1.04-1.63). In the mutually adjusted model, only perinatal factors were associated with outcomes. Several perinatal factors were associated with both disorders, but estimates were significantly higher for SCZ for low birth weight, low APGAR, and high parity. Congenital malformations were only associated with risk of SCZ, and jaundice with BD. CONCLUSIONS: Adverse perinatal factors and winter birth were the risk factors for both disorders, while severe prenatal infections were only risk a factor for SCZ. Early-life exposures were associated with a higher risk of both disorders, but may play a larger role in the development of SCZ than BD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Schizophr Bull Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Schizophr Bull Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos