Early Life Anti-Müllerian Hormone Trajectories in Infant Girls.

Chin, Helen B; Krall, Jenna R; Goldberg, Mandy; Stanczyk, Frank Z; Darge, Kassa; Stallings, Virginia A; Rogan, Walter J; Umbach, David M; Baird, Donna D

Chin, Helen B; Krall, Jenna R; Goldberg, Mandy; Stanczyk, Frank Z; Darge, Kassa; Stallings, Virginia A; Rogan, Walter J; Umbach, David M; Baird, Donna D.

Afiliación

Chin HB; From the Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA.
Krall JR; From the Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA.
Goldberg M; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Stanczyk FZ; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Darge K; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Stallings VA; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Rogan WJ; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Umbach DM; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA.
Baird DD; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

Epidemiology ; 34(4): 568-575, 2023 07 01.

Article en En | MEDLINE | ID: mdl-36943795

RESUMEN

BACKGROUND: Minipuberty is a period of increased reproductive axis activity in infancy, but the importance of this period is not well understood, especially in girls. Previous studies reported a peak in hormone concentrations at 3 to 4 months old. Our objective is to describe anti-Müllerian hormone (AMH) trajectories in the context of other minipuberty factors among healthy infant girls using longitudinal measures of AMH. METHODS: The Infant Feeding and Early Development study is a longitudinal cohort study of healthy infants, recruited from hospitals in the Philadelphia area during 2010 to 2013. We measured AMH in 153 girls who contributed 1366 serum samples across 11 study visits over 36 weeks. We also measured follicle stimulating hormone (FSH), estradiol, and ovarian characteristics. We used latent class mixed effects models to cluster trajectories of AMH concentration with age. Using linear mixed models, we estimated FSH and ovarian characteristic trajectories separately by AMH cluster. RESULTS: We classified infants into four clusters that represent patterns of AMH that were high and decreasing (decreasing), had a peak around 12 weeks or 20 weeks (early peak and middle peak), or were consistently low (low). Infants in these clusters differed in their FSH trajectories, timing of estradiol production, and ovarian characteristics. CONCLUSIONS: The AMH clusters identified suggest variation in the timing and the magnitude of the minipuberty response in infant girls. The decreasing and low clusters have not been described previously and should be further evaluated to determine whether they represent an opportunity for the early identification of later reproductive conditions.

Asunto(s)

Hormona Antimülleriana; Hormona Folículo Estimulante; Femenino; Lactante; Humanos; Estudios Longitudinales; Ovario; Estradiol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Antimülleriana / Hormona Folículo Estimulante Tipo de estudio: Observational_studies / Prognostic_studies Límite: Female / Humans / Infant Idioma: En Revista: Epidemiology Asunto de la revista: EPIDEMIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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