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COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2.
Hisham, Yasmin; Seo, Sun-Min; Kim, Sinae; Shim, Saerok; Hwang, Jihyeong; Yoo, Eun-Seon; Kim, Na-Won; Song, Chang-Seon; Jhun, Hyunjhung; Park, Ho-Young; Lee, Youngmin; Shin, Kyeong-Cheol; Han, Sun-Young; Seong, Je Kyung; Choi, Yang-Kyu; Kim, Soohyun.
Afiliación
  • Hisham Y; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
  • Seo SM; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Kim S; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
  • Shim S; College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Hwang J; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
  • Yoo ES; Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
  • Kim NW; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Song CS; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Jhun H; College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Park HY; Food Industry Infrastructure Team, Korea Food Research Institute, Wanju, Republic of Korea.
  • Lee Y; Research Group of Functional Food Materials, Korea Food Research Institute, Wanju, Republic of Korea.
  • Shin KC; Department of Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
  • Han SY; Center for Respiratory Disease, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
  • Seong JK; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam, Republic of Korea.
  • Choi YK; Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
  • Kim S; Korea Mouse Phenotyping Center, Interdisciplinary Program for Bioinformatics, and BioMAX Institute, Seoul National University, Seoul, Republic of Korea.
Front Immunol ; 14: 1098461, 2023.
Article en En | MEDLINE | ID: mdl-36936979
The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic. Several vaccines have been approved, as evidenced by the ongoing global pandemic, but the pandemic is far from over and no fully effective vaccine is yet available. One of the most critical steps in vaccine development is the selection of appropriate antigens and their proper introduction into the immune system. Therefore, in this study, we developed and evaluated two proposed vaccines composed of single and multiple SARS-CoV-2 polypeptides derived from the spike protein, namely, vaccine A and vaccine B, respectively. The polypeptides were validated by the sera of COVID-19-vaccinated individuals and/or naturally infected COVID-19 patients to shortlist the starting pool of antigens followed by in vivo vaccination to hACE2 transgenic mice. The spike multiple polypeptide vaccine (vaccine B) was more potent to reduce the pathogenesis of organs, resulting in higher protection against the SARS-CoV-2 infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / COVID-19 Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / COVID-19 Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article Pais de publicación: Suiza