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Three new coordination geometries of homoleptic Zn complexes of curcuminoids and their high antiproliferative potential.
Meza-Morales, William; Alvarez-Ricardo, Yair; Obregón-Mendoza, Marco A; Arenaza-Corona, Antonino; Ramírez-Apan, María Teresa; Toscano, Rubén A; Poveda-Jaramillo, Juan Carlos; Enríquez, Raúl G.
Afiliación
  • Meza-Morales W; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Alvarez-Ricardo Y; Department of Chemical Engineering, University of Puerto Rico-Mayaguez Route 108, Mayaguez Puerto Rico USA.
  • Obregón-Mendoza MA; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Arenaza-Corona A; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Ramírez-Apan MT; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Toscano RA; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Poveda-Jaramillo JC; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Mexico City C.P. 04510 Mexico enriquezhabib@gmail.com.
  • Enríquez RG; Laboratorio de Resonancia Magnética Nuclear, Universidad Industrial de Santander Sede Guatiguará Km. 2 vía El Refugio 681011 Piedecuesta Santander Colombia.
RSC Adv ; 13(13): 8577-8585, 2023 Mar 14.
Article en En | MEDLINE | ID: mdl-36936838
To our previously reported first crystal structure of a homoleptic zinc curcuminoid complex with square pyramidal geometry, we add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Octahedral geometry was observed in the new pseudo-polymorph of the DAC-Zn complex resulting from crystallization in DMF, while square-pyramidal geometry was obtained in DMSO. Improving crystallinity involved suppressing the phenolic interactions by etherification and esterification. The complete characterization of these complexes was carried out using SCXRD, IR, MS, EA, liquid, and solid-state NMR. Moreover, the cytotoxic activity of all complexes was evaluated. The IC50 values for the DiMeOC-Zn (7) complex were 8 or 22 times higher than for cisplatin in the U251 and HCT-15 cell lines, indicating a high antiproliferative and therapeutic potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido