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Our current clinical understanding of Candida biofilms: where are we two decades on?
Ramage, Gordon; Borghi, Elisa; Rodrigues, Célia Fortuna; Kean, Ryan; Williams, Craig; Lopez-Ribot, Jose.
Afiliación
  • Ramage G; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
  • Borghi E; Study Group for Biofilms (ESGB), European Society for Clinical Microbiology and Infectious Disease, Basel, Switzerland.
  • Rodrigues CF; Study Group for Biofilms (ESGB), European Society for Clinical Microbiology and Infectious Disease, Basel, Switzerland.
  • Kean R; Department of Health Sciences, San Paolo Medical School, Università Degli Studi di Milano, Milan, Italy.
  • Williams C; Study Group for Biofilms (ESGB), European Society for Clinical Microbiology and Infectious Disease, Basel, Switzerland.
  • Lopez-Ribot J; LEPABE-Department of Chemical Engineering, Faculty of Engineering, Cooperativa de Ensino Superior Politécnico e Universitário-CESPU, Gandra, Portugal.
APMIS ; 131(11): 636-653, 2023 Nov.
Article en En | MEDLINE | ID: mdl-36932821
Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Antifúngicos Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Antifúngicos Límite: Humans Idioma: En Revista: APMIS Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Dinamarca