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Whole-genome sequencing of Candida haemulonii species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility.
de Barros Rodrigues, Dality Keffelen; Lockhart, Shawn R; Berkow, Elizabeth L; Gade, Lalitha; Bonfietti, Lucas Xavier; Mazo Fávero Gimenes, Viviane; Silva Ruiz, Luciana; Bronze Macioni, Milena; de Souza Carvalho Melhem, Marcia.
Afiliación
  • de Barros Rodrigues DK; Programa de Pós-graduação em Doenças Infecciosas e Parasitárias, Universidade Federal do Mato Grosso do Sul, Mato Grosso do Sul, MS, Brazil.
  • Lockhart SR; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Berkow EL; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gade L; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Bonfietti LX; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde, São Paulo, SP, Brazil.
  • Mazo Fávero Gimenes V; Laboratório de Micologia Médica-LIM 53, Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Silva Ruiz L; Núcleo de Ciências Biomédicas, Instituto Adolfo Lutz, Regional Bauru, São Paulo, SP, Brazil.
  • Bronze Macioni M; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde, São Paulo, SP, Brazil.
  • de Souza Carvalho Melhem M; Universidade Paulista, São Paulo, SP, Brazil.
Med Mycol ; 61(4)2023 Apr 03.
Article en En | MEDLINE | ID: mdl-36931889
Candida haemulonii complex species is worldwide distributed, and this study aimed to evaluate the resistance to antifungal drugs in cases from Brazil and the United States, and also compare their genetic relationships. A total of 50 strains were studied; most of them from Brazil were from cases of bloodstream infections, while the strains from the United States came from cases of wounds and may be associated with diabetic patients. The vast majority of strains were resistant to amphotericin B, one of the most effective drugs, and susceptible to fluconazole. In addition, 50% of C. pseudohaemulonii strains were resistant to echinocandins. The strains from Brazil and the United States had no genetic relationship and formed two distinct groups. In three Brazilian hospitals, strains were clonal, indicating an intra-hospital transmission. Our findings contribute to guiding therapy in bloodstream fungal infections caused by C. haemulonii species and alerting for nosocomial transmission of this yeast complex species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidemia / Antifúngicos Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do norte / America do sul / Brasil Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidemia / Antifúngicos Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do norte / America do sul / Brasil Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido