Association of CTNND2 gene polymorphism with schizophrenia: Two-sample case-control study in Chinese Han population.

Chen, Zhaonian; Li, Xiaojing; Cui, Xiangzheng; Zhang, Luwen; Liu, Qing; Lu, Yanli; Wang, Xiujuan; Shi, Han; Ding, Minli; Yang, Yongfeng; Li, Wenqiang; Lv, Luxian

Chen, Zhaonian; Li, Xiaojing; Cui, Xiangzheng; Zhang, Luwen; Liu, Qing; Lu, Yanli; Wang, Xiujuan; Shi, Han; Ding, Minli; Yang, Yongfeng; Li, Wenqiang; Lv, Luxian.

Afiliación

Chen Z; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Li X; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Cui X; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Zhang L; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Liu Q; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Lu Y; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Wang X; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Shi H; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Ding M; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Yang Y; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Li W; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Lv L; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.

Int J Psychiatry Med ; 58(5): 433-448, 2023 09.

Article en En | MEDLINE | ID: mdl-36930964

RESUMEN

OBJECTIVES: Genetic factors play an important role in the etiology of schizophrenia (SZ). Catenin Delta 2 (CTNND2) is one of the genes regulating neuronal development in the brain. It is unclear whether CTNND2 is involved in SZ. With the hypothesis that CTNND2 may be a risk gene for SZ, we performed a case-control association analysis to investigate if CTNND2 gene single nucleotide polymorphisms (SNPs) are implicated in SZ in a Han Chinese population. MATERIALS AND METHODS: We recruited subjects from 2010 to 2022 from the Han population of northern Henan and divided them into two case-control samples, including a discovery sample (SZ = 528 and controls = 528) and replication sample (SZ = 2458 and controls = 6914). Twenty-one SNPs were genotyped on the Illumina BeadStation 500G platform using GoldenGate technology and analyzed by PLINK. The Positive and Negative Syndrome Scale (PANSS) was used to assess clinical symptoms. RESULTS: Rs16901943, rs7733427, and rs2168878 SNPs were associated with SZ (Chi2 = 7.484, 11.576, and 5.391, respectively, df = 1; p = 0.006, 0.00067, and 0.02, respectively) in the two samples. Rs10058868 was associated with SZ in male patients in the discovery sample (Chi2 = 6.264, df = 1, p = .044). Only the relationship with rs7733427 survived Bonferroni correction. Linkage disequilibrium block three haplotypes were associated with SZ in the discovery and total sample. PANSS analysis of the four SNPs implicated rs10058868 and rs2168878 in symptoms of depression and excitement, respectively, in the patients with SZ. CONCLUSION: Four SNPs of the CTNND2 gene were identified as being correlated with SZ. This gene may be involved in susceptibility to SZ.

Asunto(s)

Predisposición Genética a la Enfermedad; Esquizofrenia; Humanos; Masculino; Estudios de Casos y Controles; Catenina delta; Estudios de Asociación Genética; Esquizofrenia/genética; Pueblos del Este de Asia; Genotipo; Polimorfismo de Nucleótido Simple; Frecuencia de los Genes

Palabras clave

Catenin delta 2; Schizophrenia; association analyses; positive and negative syndrome scale; single nucleotide polymorphism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Predisposición Genética a la Enfermedad Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Int J Psychiatry Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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