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Magnetic Response Combined with Bioactive Ion Therapy: A RONS-Scavenging Theranostic Nanoplatform for Thrombolysis and Renal Ischemia-Reperfusion Injury.
Xu, Lian; Luo, Ying; Du, Qianying; Zhang, Wenli; Hu, Liu; Fang, Ni; Wang, Junrui; Liu, Jia; Zhou, Jun; Zhong, Yixin; Liu, Yun; Ran, Haitao; Guo, Dajing; Xu, Jie.
Afiliación
  • Xu L; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Luo Y; Chongqing Key Laboratory of Ultrasound Molecular Imaging and Department of Ultrasound, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Du Q; State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing 400016, PR China.
  • Zhang W; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Hu L; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Fang N; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Wang J; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Liu J; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Zhou J; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Zhong Y; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Liu Y; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Ran H; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Guo D; Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
  • Xu J; Chongqing Key Laboratory of Ultrasound Molecular Imaging and Department of Ultrasound, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
ACS Nano ; 17(6): 5695-5712, 2023 03 28.
Article en En | MEDLINE | ID: mdl-36930590
Currently, the limited efficacy of antithrombotic treatments is attributed to the inadequacy of pure drugs and the low ability of drugs to target the thrombus site. More importantly, timely thrombolysis is essential to reduce the sequelae of cardiovascular disease, but ischemia-reperfusion injury (IRI) remains a major challenge that must be solved after blood flow recovery. Herein, a multifunctional therapeutic nanoparticle (NP) based on Fe3O4 and strontium ions encapsulated in mesoporous polydopamine was successfully constructed and then loaded with TNK-tPA (FeM@Sr-TNK NPs). The NPs (59.9 min) significantly prolonged the half-life of thrombolytic drugs, which was 3.04 times that of TNK (19.7 min), and they had good biological safety. The NPs were shown to pass through vascular models with different inner diameters, curvatures, and stenosis under magnetic targeting and to enable accurate diagnosis of thrombi by photoacoustic imaging. NPs combined with the magnetic hyperthermia technique were used to accelerate thrombolysis and quickly open blocked blood vessels. Then, renal IRI-induced functional metabolic disorder and tissue damage were evidently attenuated by scavenging toxic reactive oxygen and nitrogen species and through the protective effects of bioactive ion therapy, including reduced apoptosis, increased angiogenesis, and inhibited fibrosis. In brief, we constructed a multifunctional nanoplatform for integrating a "diagnosis-therapy-protection" approach to achieve comprehensive management from thrombus to renal IRI, promoting the advancement of related technologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Daño por Reperfusión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Nano Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Daño por Reperfusión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Nano Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos