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Diagnostic accuracy of pleural fluid to serum carcinoembryonic antigen ratio and delta value for malignant pleural effusion: findings from two cohorts.
Jiang, Meng-Ping; Wen, Jian-Xun; Hai, Ling; Jiang, Ting-Wang; Huang, Jin-Hong; Chen, Hong; Wang, Ya-Fei; Zheng, Wen-Qi; Hu, Zhi-De; Yan, Li.
Afiliación
  • Jiang MP; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Wen JX; Department of Medical Experiment Center, The College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Hai L; Department of Pathology, The College of Basic Medical, Inner Mongolia Medical University, Hohhot, China.
  • Jiang TW; Department of Pathology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Huang JH; Department of Key Laboratory, The Affiliated Changshu Hospital of Xuzhou Medical University, Suzhou, China.
  • Chen H; Department of Pulmonary and Critical Care Medicine, The Affiliated Changshu Hospital of Xuzhou Medical University, Suzhou, China.
  • Wang YF; Department of Pulmonary and Critical Care Medicine, The Affiliated Changshu Hospital of Xuzhou Medical University, Suzhou, China.
  • Zheng WQ; Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Hu ZD; Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Yan L; Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China.
Ther Adv Respir Dis ; 17: 17534666231155745, 2023.
Article en En | MEDLINE | ID: mdl-36927281
BACKGROUND: Pleural fluid (PF) carcinoembryonic antigen (CEA) is a widely used diagnostic marker for malignant pleural effusion (MPE). Recent studies revealed that PF to serum CEA was also a promising diagnostic parameter for MPE. OBJECTIVE: We aimed to investigate whether PF to serum CEA ratio and delta CEA (PF minus serum CEA) provided added value to PF CEA in diagnosing MPE. METHODS: Patients with pleural effusion in a retrospective cohort (BUFF) and a prospective cohort (SIMPLE) were included. The clinical characteristics of the patients were extracted from their medical records. The diagnostic value of CEA ratio and delta CEA was estimated by a receiver operating characteristics (ROC) curve, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). RESULTS: A total of 148 patients in the BUFF cohort and 164 patients in the SIMPLE cohort were enrolled. The BUFF cohort had 46 MPE patients and 102 benign pleural effusion (BPE) patients, and the SIMPLE cohort had 85 MPE patients and 79 BPE patients. In both cohorts, MPE patients had significantly higher PF CEA, serum CEA, CEA ratio, and delta CEA. The area under ROC curves (AUCs) of PF CEA, CEA ratio, and delta CEA were 0.78 (95% CI: 0.67-0.88), 0.80 (95% CI: 0.72-0.89) and 0.83 (95% CI: 0.75-0.91) in the BUFF cohort, and 0.89 (95% CI: 0.83-0.94), 0.86 (95% CI: 0.80-0.92), and 0.84 (95% CI: 0.78-0.91) in the SIMPLE cohort. The differences between the AUCs of PF CEA, CEA ratio, and delta CEA did not reach statistical significance. The continuous NRI and IDI of CEA ratio and delta CEA were <0. CONCLUSION: CEA ratio and delta value cannot provide added diagnostic value to PF CEA. The simultaneous determination of serum and PF CEA should not be adopted in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derrame Pleural / Derrame Pleural Maligno Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Ther Adv Respir Dis Asunto de la revista: PNEUMOLOGIA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derrame Pleural / Derrame Pleural Maligno Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Ther Adv Respir Dis Asunto de la revista: PNEUMOLOGIA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido