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Polyoxidovanadates as a pharmacological option against brain aging.
Díaz, Alfonso; Vázquez-Roque, Rubén; Carreto-Meneses, Karen; Moroni-González, Diana; Moreno-Rodríguez, José Albino; Treviño, Samuel.
Afiliación
  • Díaz A; Department of Pharmacy, Faculty of Chemistry Science, University Autonomous of Puebla, 22 South. FC91, University City, Puebla C.P. 72560, Mexico.
  • Vázquez-Roque R; Neuropsychiatry laboratory, Physiology Institute, University Autonomous of Puebla, 14 South. University City, Puebla C.P. 72560, Mexico.
  • Carreto-Meneses K; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla, 14 South. FCQ1, University City, Puebla C.P. 72560, Mexico.
  • Moroni-González D; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla, 14 South. FCQ1, University City, Puebla C.P. 72560, Mexico.
  • Moreno-Rodríguez JA; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla, 14 South. FCQ1, University City, Puebla C.P. 72560, Mexico.
  • Treviño S; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla, 14 South. FCQ1, University City, Puebla C.P. 72560, Mexico. Electronic address: samuel.trevino@correo.buap.mx.
J Chem Neuroanat ; 129: 102256, 2023 04.
Article en En | MEDLINE | ID: mdl-36921908
The world population is aging rapidly, and chronic diseases associated are cardiometabolic syndrome, cancer, and neurodegenerative diseases. Oxidative stress and inflammation are typical hallmarks in them. Polyoxidovanadates (POVs) have shown interesting pharmacological actions against chronic diseases. This work aimed to evaluate the POV effect on hippocampal neuroinflammation, redox balance, and recognition memory in the aging of rats. Rats 18 months old were administered a daily dose of sodium metavanadate (MV), decavanadate (DV), Metformin (Metf), or MetfDeca for two months. Results showed that short-term and long-term recognition memory improved by 28 % and 16 % (DV), 19 % and 20 % (Metf), and 21 % and 27 % (MetfDeca). In hippocampi, reactive oxygen species, IL-1ß, and TNF-α, after DV, Metf, and MetfDeca decreased at similar concentrations to young adult control, while lipid peroxidation substantially ameliorated. Additionally, superoxide dismutase and catalase activity increased by 41 % and 42 % (DV), 39 % and 41 % (Metf), and 75 % and 73 % (MetfDeca). POV treatments reduced Nrf2 and GFAP immunoreactivity in CA1 (70-87.5 %), CA3 (60-80 %), and DG (57-89 %). Metformin treatment showed a minor effect, while MV treatment did not improve any parameters. Although DV, Metf, and MetfDeca treatments showed similar results, POVs doses were 16-fold fewer than Metformin. In conclusion, DV and MetfDeca could be pharmacological options to reduce age-related neuronal damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Metformina Límite: Animals Idioma: En Revista: J Chem Neuroanat Asunto de la revista: ANATOMIA / NEUROLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Metformina Límite: Animals Idioma: En Revista: J Chem Neuroanat Asunto de la revista: ANATOMIA / NEUROLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Países Bajos