Targeting Caspase-3 Gene in rCHO Cell Line by CRISPR/Cas9 Editing Tool and Its Effect on Protein Production in Manipulated Cell Line.

Rahimi, Amirabbas; Karimipoor, Morteza; Mahdian, Reza; Alipour, Atefeh; Hosseini, Sadi; Kaghazian, Hooman; Abbasi, Abdolrahim; Shahsavarani, Hosein; Shokrgozar, Mohammad Ali

Rahimi, Amirabbas; Karimipoor, Morteza; Mahdian, Reza; Alipour, Atefeh; Hosseini, Sadi; Kaghazian, Hooman; Abbasi, Abdolrahim; Shahsavarani, Hosein; Shokrgozar, Mohammad Ali.

Afiliación

Rahimi A; Laboratory of Regenerative Medicine and Biomedical Innovations, Department of National Cell Bank, Pasteur Institute of Iran, Tehran, Iran.
Karimipoor M; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Mahdian R; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Alipour A; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Hosseini S; Department of Nano-Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
Kaghazian H; Laboratory of Regenerative Medicine and Biomedical Innovations, Department of National Cell Bank, Pasteur Institute of Iran, Tehran, Iran.
Abbasi A; Department of Research & Development, Production & Research Complex, Pasteur Institute of Iran, Tehran, Iran.
Shahsavarani H; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Shokrgozar MA; Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Iran J Pharm Res ; 21(1): e130236, 2022 Dec.

Article en En | MEDLINE | ID: mdl-36915405

Palabras clave

Apoptosis; CHO cells; CRISPR/Cas9; Caspase-3; Gene Editing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Pharm Res Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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