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Sex differences in the relationship between hepatic steatosis, mood and anxiety disorders.
Goulart, Alessandra C; Bianchi, Leonardo L T; Bismarchi, Danielle; Miname, Márcio H; Lourenção, Ana Carolina Melillo; Henares, Bruna B; Garcia, Ariane T; de Almeida, Mozar S; Machado, Thiago A O; Syllos, Danielli H; Rienzo, Marcos; Wang, Yuan-Pang.
Afiliación
  • Goulart AC; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil. Electronic address: alessandra.cgoulart@hsl.org.br.
  • Bianchi LLT; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Bismarchi D; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Miname MH; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Lourenção ACM; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Henares BB; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Garcia AT; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • de Almeida MS; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Machado TAO; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Syllos DH; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Rienzo M; Health Promotion and Check-up Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
  • Wang YP; Department of Psychiatry, School of Medicine, Universidade de Sao Paulo, São Paulo, SP, Brazil.
J Psychosom Res ; 168: 111216, 2023 05.
Article en En | MEDLINE | ID: mdl-36913766
OBJECTIVE: To investigate the association between non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), mental symptoms (mood, anxiety disorders and distress) by sex. METHODS: This a cross-sectional study performed in working-age adults from a Health Promotion Center (primary care) in São Paulo, Brazil. Self-reported mental symptoms from rating scales (21-item Beck Anxiety Inventory, Patient Health Questionnaire-9, and K6 distress scale) were evaluated by hepatic steatosis (NAFLD and ALD). Logistic regression models estimated the association between hepatic steatosis subtypes and mental symptoms by Odds ratios (OR) adjusted by confounders in the total sample and sex stratified. RESULTS: Among 7241 participants (70.5% men, median age: 45 years), the frequency of steatosis was of 30.7% (25.1% NAFLD), being higher in men than women (70.5% vs. 29.5%, p < 0.0001), regardless of the steatosis subtype. Metabolic risk factors were similar in both subtypes of steatosis, but not mental symptoms. Overall, NAFLD was inversely associated with anxiety (OR = 0.75, 95%CI 0.63-0.90) and positively associated with depression (OR = 1.17, 95%CI 1.00-1.38). On the other hand, ALD was positively associated with anxiety (OR = 1.51; 95%CI 1.15-2.00). In sex-stratified analyses, only men presented an association of anxiety symptoms with NAFLD (OR = 0.73; 95%CI 0.60-0.89) and ALD (OR = 1.60; 95%CI 1.18-2.16). CONCLUSIONS: The complex association between different types of steatosis (NAFLD and ALD), mood and anxiety disorders indicates the need for a deeper understanding of their common causal pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Psychosom Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Psychosom Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido