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Parental smoking and risk of hypospadias: An updated meta-analysis of observational studies.
Ye, Zi-Han; Chen, Hong-Song; Zhang, Zhi-Cheng; Wang, Xiao; Liu, Xing; Wei, Guang-Hui.
Afiliación
  • Ye ZH; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Chen HS; Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China.
  • Zhang ZC; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China.
  • Wang X; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Liu X; Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China.
  • Wei GH; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China.
Front Pediatr ; 11: 1003037, 2023.
Article en En | MEDLINE | ID: mdl-36911013
Background: Inconsistent relationships have been shown between cigarette smoking and hypospadias in offspring. The purpose of this study was to summarize epidemiological evidence to evaluate the relationship between parental smoking and the risk of hypospadias. Methods: Up until October 2022, PubMed, EMBASE, Web of Science, and the Cochrane Library were systematically searched for qualified research. The summary RRs and 95% CIs were calculated using either a fixed-effects or a random-effects model. There were subgroup analyses undertaken to identify potential sources of heterogeneity. Results: 44 studies with 16,637,830 participants were included in our meta-analysis. Overall, maternal active smoking [risk ratio (RR) = 0.94; 95% confidence interval (CI): 0.90-0.99; P < 0.01] was significantly associated with the risk of hypospadias. And neither paternal smoking (RR = 1.00; 95% CI: 0.86-1.15) nor maternal passive smoking (RR = 0.91; 95% CI: 0.60-1.23) was associated with the risk of hypospadias. Conclusion: Our study discovered an association between maternal active smoking and a decreased risk of hypospadias, which may be due to the effect of smoking on androgen. However, as numerous studies have proved that cigarette smoking during pregnancy increases the risk of overall birth abnormalities in offspring, quitting cigarettes before pregnancy positively influences the health of offspring and should be advocated worldwide. Systematic review registration: [www.crd.york.ac.uk/prospero], identifier [CRD42022319378].
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Front Pediatr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Front Pediatr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza