Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes.

Kaul, Sanjiv; Methner, Carmen; Cao, Zhiping; Mishra, Anusha

Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes.

Kaul, Sanjiv; Methner, Carmen; Cao, Zhiping; Mishra, Anusha.

Afiliación

Kaul S; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Methner C; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Cao Z; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Mishra A; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

JACC Basic Transl Sci ; 8(2): 204-220, 2023 Feb.

Article en En | MEDLINE | ID: mdl-36908667

RESUMEN

Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.

Palabras clave

CHP, capillary hydrostatic pressure; MBF, myocardial blood flow; MCE, myocardial contrast echocardiography; NG2, neural glial antigen-2; acute myocardial infarction; blood flow; necrosis; no reflow; pericytes

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google