Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.

Rudman, Najda; Kaur, Simranjeet; Simunovic, Vesna; Kifer, Domagoj; Soic, Dinko; Keser, Toma; Stambuk, Tamara; Klaric, Lucija; Pociot, Flemming; Morahan, Grant; Gornik, Olga

Rudman, Najda; Kaur, Simranjeet; Simunovic, Vesna; Kifer, Domagoj; Soic, Dinko; Keser, Toma; Stambuk, Tamara; Klaric, Lucija; Pociot, Flemming; Morahan, Grant; Gornik, Olga.

Afiliación

Rudman N; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Kaur S; Steno Diabetes Center Copenhagen, Herlev, Denmark.
Simunovic V; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Kifer D; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Soic D; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Keser T; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Stambuk T; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Klaric L; Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK.
Pociot F; Steno Diabetes Center Copenhagen, Herlev, Denmark.
Morahan G; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gornik O; Centre for Diabetes Research, The Harry Perkins Institute for Medical Research, University of Western Australia, Perth, WA, Australia. grant.morahan@perkins.org.au.

Diabetologia ; 66(6): 1071-1083, 2023 06.

Article en En | MEDLINE | ID: mdl-36907892

Asunto(s)

Diabetes Mellitus Tipo 1; Adolescente; Niño; Humanos; Glicosilación; Diabetes Mellitus Tipo 1/genética; Glicómica/métodos; Estudios de Seguimiento; N-Acetilglucosaminiltransferasas/genética; Inmunoglobulina G/metabolismo; Proteínas Sanguíneas/metabolismo; Polisacáridos/metabolismo

Palabras clave

C3; GWAS; IgG N-glycosylation; MGAT3; ST6GAL1; plasma protein N-glycosylation; type 1 diabetes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Diabetologia Año: 2023 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Alemania

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