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Nanoplastics causes extensive congenital malformations during embryonic development by passively targeting neural crest cells.
Wang, Meiru; Rücklin, Martin; Poelmann, Robert E; de Mooij, Carmen L; Fokkema, Marjolein; Lamers, Gerda E M; de Bakker, Merijn A G; Chin, Ernest; Bakos, Lilla J; Marone, Federica; Wisse, Bert J; de Ruiter, Marco C; Cheng, Shixiong; Nurhidayat, Luthfi; Vijver, Martina G; Richardson, Michael K.
Afiliación
  • Wang M; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands.
  • Rücklin M; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands.
  • Poelmann RE; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, The Netherlands.
  • de Mooij CL; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Fokkema M; Institute of Psychology, Methodology and Statistics, Pieter de la Court Building, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands.
  • Lamers GEM; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • de Bakker MAG; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Chin E; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Bakos LJ; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Marone F; Swiss Light Source, Paul Scherrer Institut, Photon Science Department, Forschungsstrasse 111, CH-5232 Villigen, Switzerland.
  • Wisse BJ; Department of Anatomy & Embryology, Leiden University Medical Center, The Netherlands.
  • de Ruiter MC; Department of Anatomy & Embryology, Leiden University Medical Center, The Netherlands.
  • Cheng S; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Nurhidayat L; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands; Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  • Vijver MG; Institute of Environmental Sciences, Leiden University (CML), Van Steenis Building, Einsteinweg 2, 2333 CC Leiden, The Netherlands.
  • Richardson MK; Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The Netherlands. Electronic address: m.k.richardson@biology.leidenuniv.nl.
Environ Int ; 173: 107865, 2023 03.
Article en En | MEDLINE | ID: mdl-36907039
Nanomaterials are widespread in the human environment as pollutants, and are being actively developed for use in human medicine. We have investigated how the size and dose of polystyrene nanoparticles affects malformations in chicken embryos, and have characterized the mechanisms by which they interfere with normal development. We find that nanoplastics can cross the embryonic gut wall. When injected into the vitelline vein, nanoplastics become distributed in the circulation to multiple organs. We find that the exposure of embryos to polystyrene nanoparticles produces malformations that are far more serious and extensive than has been previously reported. These malformations include major congenital heart defects that impair cardiac function. We show that the mechanism of toxicity is the selective binding of polystyrene nanoplastics nanoparticles to neural crest cells, leading to the death and impaired migration of those cells. Consistent with our new model, most of the malformations seen in this study are in organs that depend for their normal development on neural crest cells. These results are a matter of concern given the large and growing burden of nanoplastics in the environment. Our findings suggest that nanoplastics may pose a health risk to the developing embryo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatías Congénitas / Cresta Neural Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Environ Int Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatías Congénitas / Cresta Neural Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Environ Int Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos