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A parosmia severity index based on word-classification predicts olfactory abilities and impairment.
Hörberg, Thomas; Sekine, Rumi; Overbeck, Clara; Hummel, Thomas; Olofsson, Jonas K.
Afiliación
  • Hörberg T; Department of Psychology, Stockholm University, Albanovägen 12, 114 19, Stockholm, Sweden. thomas.hoerberg@psychology.su.se.
  • Sekine R; Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Germany.
  • Overbeck C; Department of Otorhinolaryngology, Jikei School of Medicine, Tokyo, Japan.
  • Hummel T; Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Germany.
  • Olofsson JK; Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Germany.
Eur Arch Otorhinolaryngol ; 280(8): 3695-3706, 2023 Aug.
Article en En | MEDLINE | ID: mdl-36906652
Parosmia is an olfactory disorder that involves distortions of specific odors that may co-occur with anosmia, loss of smell of other odors. Little is known about which odors frequently trigger parosmia, and measures of parosmia severity are lacking. Here, we present an approach to understand and diagnose parosmia that is based on semantic properties (e.g., valence) of words describing odor sources ("fish", "coffee", etc.). Using a data-driven method based on natural language data, we identified 38 odor descriptors. Descriptors were evenly dispersed across an olfactory-semantic space, which was based on key odor dimensions. Parosmia patients (n = 48) classified the corresponding odors in terms of whether they trigger parosmic or anosmic sensations. We investigated whether these classifications are related to semantic properties of the descriptors. Parosmic sensations were most often reported for words describing unpleasant odors of inedibles that are highly associated to olfaction (e.g., "excrement"). Based on PCA modeling, we derived the Parosmia Severity Index-a measure of parosmia severity that can be determined solely from our non-olfactory behavioral task. This index predicts olfactory-perceptual abilities, self-reported olfactory impairment, and depression. We thus provide a novel approach for investigating parosmia and establishing its severity that does not require odor exposure. Our work may enhance our understanding of how parosmia changes over time and how it is expressed differently across individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olfato / Trastornos del Olfato Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olfato / Trastornos del Olfato Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania