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Exposure to a rotating magnetic field as a method of increasing the skin permeability of active pharmaceutical ingredients.
Rakoczy, Rafal; Nowak, Anna; Konopacki, Maciej; Kordas, Marian; Kucharski, Lukasz; Ossowicz-Rupniewska, Paula.
Afiliación
  • Rakoczy R; West Pomeranian University of Technology in Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical and Process Engineering, Piastów Ave. 42, 71-065 Szczecin, Poland.
  • Nowak A; Pomeranian Medical University in Szczecin, Department of Cosmetic and Pharmaceutical Chemistry, Powstanców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
  • Konopacki M; West Pomeranian University of Technology in Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical and Process Engineering, Piastów Ave. 42, 71-065 Szczecin, Poland.
  • Kordas M; West Pomeranian University of Technology in Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical and Process Engineering, Piastów Ave. 42, 71-065 Szczecin, Poland.
  • Kucharski L; Pomeranian Medical University in Szczecin, Department of Cosmetic and Pharmaceutical Chemistry, Powstanców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
  • Ossowicz-Rupniewska P; West Pomeranian University of Technology in Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical Organic Technology and Polymeric Materials, Piastów Ave. 42, 71-065 Szczecin, Poland. Electronic address: possowicz@zut.edu.pl.
Eur J Pharm Biopharm ; 185: 183-189, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36905969
The paper presents a method of increasing the permeability of various active substances through the skin by means of a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) such as caffeine, ibuprofen, naproxen, ketoprofen, and paracetamol. Various concentrations of active substance solutions in ethanol were used in the research, corresponding to those in commercial preparations. Each experiment was conducted for 24 h. It was shown that, regardless of the active compound used, an increase in drug transport through the skin was observed with RMF exposure. Furthermore, the release profiles depended on the active substance used. Exposure to a rotating magnetic field has been shown to effectively increase the permeability of an active substance through the skin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cetoprofeno Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cetoprofeno Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos