Visible Light Conjugation with Triazolinediones as a Route to Degradable Poly(ethylene glycol)-Lipids for mRNA Lipid Nanoparticle Formulation.

Golba, Bianka; Soete, Matthieu; Zhong, Zifu; Sanders, Niek; Du Prez, Filip E; Houck, Hannes A; De Geest, Bruno G

Golba, Bianka; Soete, Matthieu; Zhong, Zifu; Sanders, Niek; Du Prez, Filip E; Houck, Hannes A; De Geest, Bruno G.

Afiliación

Golba B; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
Soete M; Polymer Chemistry Research group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000, Ghent, Belgium.
Zhong Z; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
Sanders N; Department of Veterinary and Biosciences, Ghent University, Heidestraat 19, 9820, Merelbeke, Belgium.
Du Prez FE; Polymer Chemistry Research group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000, Ghent, Belgium.
Houck HA; Polymer Chemistry Research group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000, Ghent, Belgium.
De Geest BG; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Angew Chem Int Ed Engl ; 62(23): e202301102, 2023 06 05.

Article en En | MEDLINE | ID: mdl-36896730

Asunto(s)

Nanopartículas; Polietilenglicoles; Animales; Ratones; ARN Mensajero/genética; Liposomas; Lípidos

Palabras clave

Degradable PEG; Drug Delivery; Lipid Nanoparticles; Multifunctional PEG; mRNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Nanopartículas Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Alemania

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