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Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants in non-human primates.
Pavot, Vincent; Berry, Catherine; Kishko, Michael; Anosova, Natalie G; Li, Lu; Tibbitts, Tim; Huang, Dean; Raillard, Alice; Gautheron, Sylviane; Gutzeit, Cindy; Koutsoukos, Marguerite; Chicz, Roman M; Lecouturier, Valerie.
Afiliación
  • Pavot V; Sanofi, Marcy l'Etoile, France.
  • Berry C; Sanofi, Marcy l'Etoile, France.
  • Kishko M; Sanofi, Cambridge, MA, USA.
  • Anosova NG; Sanofi, Cambridge, MA, USA.
  • Li L; Sanofi, Cambridge, MA, USA.
  • Tibbitts T; Sanofi, Cambridge, MA, USA.
  • Huang D; Sanofi, Cambridge, MA, USA.
  • Raillard A; Sanofi, Marcy l'Etoile, France.
  • Gautheron S; Sanofi, Marcy l'Etoile, France.
  • Gutzeit C; GSK, Rixensart, Belgium.
  • Koutsoukos M; GSK, Wavre, Belgium.
  • Chicz RM; Sanofi, Waltham, MA, USA.
  • Lecouturier V; Sanofi, Marcy l'Etoile, France. valerie.lecouturier@sanofi.com.
Nat Commun ; 14(1): 1309, 2023 03 10.
Article en En | MEDLINE | ID: mdl-36894558
The rapid spread of the SARS-CoV-2 Omicron subvariants, despite the implementation of booster vaccination, has raised questions about the durability of protection conferred by current vaccines. Vaccine boosters that can induce broader and more durable immune responses against SARS-CoV-2 are urgently needed. We recently reported that our Beta-containing protein-based SARS-CoV-2 spike booster vaccine candidates with AS03 adjuvant (CoV2 preS dTM-AS03) elicited robust cross-neutralizing antibody responses at early timepoints against SARS-CoV-2 variants of concern in macaques primed with mRNA or protein-based subunit vaccine candidates. Here we demonstrate that the monovalent Beta vaccine with AS03 adjuvant induces durable cross-neutralizing antibody responses against the prototype strain D614G as well as variants Delta (B.1.617.2), Omicron (BA.1 and BA.4/5) and SARS-CoV-1, that are still detectable in all macaques 6 months post-booster. We also describe the induction of consistent and robust memory B cell responses, independent of the levels measured post-primary immunization. These data suggest that a booster dose with a monovalent Beta CoV2 preS dTM-AS03 vaccine can induce robust and durable cross-neutralizing responses against a broad spectrum of variants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido