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High prevalence and incidence of gonorrhoea and chlamydia in young women eligible for HIV pre-exposure prophylaxis in South Africa and Zimbabwe: results from the HPTN 082 trial.
Delany-Moretlwe, Sinead; Mgodi, Nyaradzo; Bekker, Linda-Gail; Baeten, Jared M; Li, Chuwen; Donnell, Deborah; Agyei, Yaw; Lennon, Denni; Rose, Scott M; Mokgatle, Marcia; Kassim, Sheetal; Mukaka, Shorai; Adeyeye, Adeola; Celum, Connie.
Afiliación
  • Delany-Moretlwe S; Wits RHI, University of the Witwatersrand, Johannesburg, South Africa sdelany@wrhi.ac.za.
  • Mgodi N; Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.
  • Bekker LG; Desmond Tutu Health Centre, University of Cape Town, Cape Town, South Africa.
  • Baeten JM; Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, USA.
  • Li C; Gilead Sciences, Foster City, California, USA.
  • Donnell D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Agyei Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Lennon D; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Rose SM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Mokgatle M; FHI 360, Durham, North Carolina, USA.
  • Kassim S; Wits RHI, University of the Witwatersrand, Johannesburg, South Africa.
  • Mukaka S; Desmond Tutu Health Centre, University of Cape Town, Cape Town, South Africa.
  • Adeyeye A; Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.
  • Celum C; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Sex Transm Infect ; 99(7): 433-439, 2023 11.
Article en En | MEDLINE | ID: mdl-36889914
INTRODUCTION: We investigated the prevalence, incidence and factors associated with sexually transmitted infections (STIs) among young African women seeking HIV pre-exposure prophylaxis (PrEP). METHODS: HPTN 082 was a prospective, open-label PrEP study enrolling HIV-negative sexually active women aged 16-25 years in Cape Town and Johannesburg, South Africa, and Harare, Zimbabwe. Endocervical swabs from enrolment, months 6 and 12 were tested for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) by nucleic acid amplification, and Trichomonas vaginalis (TV) by a rapid test. Intracellular tenofovir-diphosphate (TFV-DP) concentrations in dried blood spots were measured at months 6 and 12. Associations between risk characteristics and STI outcomes were assessed using Poisson regression. RESULTS: Of 451 enrolled participants, 55% had an STI detected at least once. CT incidence was 27.8 per 100 person-years (py) (95% CI 23.1, 33.2), GC incidence was 11.4 per 100 py (95% CI 8.5, 15.0) and TV incidence was 6.7 per 100 py (95% CI 4.5, 9.5). 66% of incident infections were diagnosed in women uninfected at baseline. Baseline cervical infection (GC or CT) risk was highest in Cape Town (relative risk (RR) 2.38, 95% CI 1.35, 4.19) and in those not living with family (RR 1.87, 95% 1.13, 3.08); condom use was protective (RR 0.67, 95% CI 0.45, 0.99). Incident CT was associated with baseline CT (RR 2.01; 95% CI 1.28, 3.15) and increasing depression score (RR 1.05; 95% CI 1.01, 1.09). Incident GC was higher in Cape Town (RR 2.40; 95% CI 1.18, 4.90) and in participants with high PrEP adherence (TFV-DP concentrations ≥700 fmol/punch) (RR 2.04 95% CI 1.02, 4.08). CONCLUSION: Adolescent girls and young women seeking PrEP have a high prevalence and incidence of curable STIs. Alternatives to syndromic management for diagnosis and treatment are needed to reduce the burden of STIs in this population. TRIAL REGISTRATION NUMBER: NCT02732730.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trichomonas vaginalis / Gonorrea / Enfermedades de Transmisión Sexual / Infecciones por VIH / Profilaxis Pre-Exposición Tipo de estudio: Etiology_studies / Incidence_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Sex Transm Infect Asunto de la revista: DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trichomonas vaginalis / Gonorrea / Enfermedades de Transmisión Sexual / Infecciones por VIH / Profilaxis Pre-Exposición Tipo de estudio: Etiology_studies / Incidence_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Sex Transm Infect Asunto de la revista: DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido