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Sex Differences in Cardiovascular Disease and Cardiovascular Risk Estimation in Patients With Type 1 Diabetes.
Dei Cas, Alessandra; Aldigeri, Raffaella; Mantovani, Alessandro; Masulli, Maria; Palmisano, Luisa; Cavalot, Franco; Bonomo, Katia; Baroni, Marco Giorgio; Cossu, Efisio; Cavallo, Gisella; Cimini, Flavia Agata; Buzzetti, Raffaella; Mignogna, Carmen; Leonetti, Frida; Bacci, Simonetta; Trevisan, Roberto; Morieri, Mario Luca; Pollis, Riccardo Maria; Targher, Giovanni; Vigili de Kreutzenberg, Saula.
Afiliación
  • Dei Cas A; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Aldigeri R; Division of Nutritional and Metabolic Sciences, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, Italy.
  • Mantovani A; Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
  • Masulli M; Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, 37124 Verona, Italy.
  • Palmisano L; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
  • Cavalot F; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
  • Bonomo K; Diabetes and Metabolic Diseases Unit, San Luigi Gonzaga University Hospital, 10043 Turin, Italy.
  • Baroni MG; Diabetes and Metabolic Diseases Unit, San Luigi Gonzaga University Hospital, 10043 Turin, Italy.
  • Cossu E; Department of Clinical Medicine, Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
  • Cavallo G; Neuroendocrinology and Metabolic Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy.
  • Cimini FA; Unit of Diabetology, Policlinico Universitario of Cagliari, 09124 Cagliari, Italy.
  • Buzzetti R; Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
  • Mignogna C; Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
  • Leonetti F; Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
  • Bacci S; Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
  • Trevisan R; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, 00185 Rome, Italy.
  • Morieri ML; Section of Endocrinology, Department of Medicine, IRCCS, Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo (FG), Italy.
  • Pollis RM; Department of Medicine and Surgery, University of Milan Bicocca, 20126 Milan, Italy.
  • Targher G; Metabolic Diseases, Department of Medicine, University of Padua, 35128 Padua, Italy.
  • Vigili de Kreutzenberg S; Metabolic Diseases, Department of Medicine, University of Padua, 35128 Padua, Italy.
J Clin Endocrinol Metab ; 108(9): e789-e798, 2023 08 18.
Article en En | MEDLINE | ID: mdl-36881927
CONTEXT: Patients with type 1 diabetes (T1D) have higher cardiovascular disease (CVD) risk than the general population. OBJECTIVE: This observational study aims to evaluate sex-related differences in CVD prevalence and CVD risk estimates in a large cohort of T1D adults. METHODS: We conducted a multicenter, cross-sectional study involving 2041 patients with T1D (mean age 46 years; 44.9% women). In patients without pre-existing CVD (primary prevention), we used the Steno type 1 risk engine to estimate the 10-year risk of developing CVD events. RESULTS: CVD prevalence (n = 116) was higher in men than in women aged ≥55 years (19.2 vs 12.8%, P = .036), but comparable between the 2 sexes in those aged <55 years (P = .91). In patients without pre-existing CVD (n = 1925), mean 10-year estimated CVD risk was 15.4 ± 0.4% without any significant sex difference. However, stratifying this patient group by age, the 10-year estimated CVD risk was significantly higher in men than in women until age 55 years (P < .001), but this risk equalized after this age. Carotid artery plaque burden was significantly associated with age ≥55 years and with a medium and high 10-year estimated CVD risk, without any significant sex difference. Diabetic retinopathy and sensory-motor neuropathy were also associated with higher 10-year CVD risk and female sex. CONCLUSION: Both men and women with T1D are at high CVD risk. The 10-year estimated CVD risk was higher in men aged <55 years than in women of similar age, but these sex differences disappeared at age ≥55 years, suggesting that female sex was no longer protective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 1 Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 1 Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos