Azithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathway.

Song, Yun; Fu, Wenhuan; Zhang, Youzhi; Huang, Doudou; Wu, Jian; Tong, Shuangmei; Zhong, Mingkang; Cao, Huifang; Wang, Bin

Song, Yun; Fu, Wenhuan; Zhang, Youzhi; Huang, Doudou; Wu, Jian; Tong, Shuangmei; Zhong, Mingkang; Cao, Huifang; Wang, Bin.

Afiliación

Song Y; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fu W; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhang Y; Department of Respiration, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Huang D; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wu J; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Tong S; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhong M; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China. mkzhong_hs@126.com.
Cao H; Department of Respiratory and Critical Medicine, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Shanghai, 200040, China. hfcao999@126.com.
Wang B; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, 200040, China. hsbinwang@163.com.

Respir Res ; 24(1): 69, 2023 Mar 06.

Article en En | MEDLINE | ID: mdl-36879222

Asunto(s)

Fumar Cigarrillos; Enfermedad Pulmonar Obstructiva Crónica; Animales; Humanos; Ratones; Ratas; Azitromicina/farmacología; Azitromicina/uso terapéutico; Glutamato-Cisteína Ligasa; Ratones Endogámicos C57BL; Factor 2 Relacionado con NF-E2; Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico; Enfermedad Pulmonar Obstructiva Crónica/prevención & control; Ratas Sprague-Dawley; Transducción de Señal; Glutatión/metabolismo

Palabras clave

Airway epithelial barrier dysfunction; Azithromycin; Cigarette smoke; GSH metabolism; Nrf2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Fumar Cigarrillos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Respir Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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