Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.

Li, Xingguo; Wang, Xuenan; Chen, Chao; Zhang, Enyu; Zhang, Yuan; Li, Hongkun; Lei, Yu; Lou, Zhenkai; Zhang, Fan

Li, Xingguo; Wang, Xuenan; Chen, Chao; Zhang, Enyu; Zhang, Yuan; Li, Hongkun; Lei, Yu; Lou, Zhenkai; Zhang, Fan.

Afiliación

Li X; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Wang X; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Chen C; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Zhang E; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Zhang Y; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Li H; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Lei Y; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Lou Z; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Zhang F; Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. Electronic address: zhangfan4@kmmu.edu.cn.

Life Sci ; 320: 121555, 2023 May 01.

Article en En | MEDLINE | ID: mdl-36878279

Asunto(s)

Degeneración del Disco Intervertebral; Disco Intervertebral; Ratones; Animales; Degeneración del Disco Intervertebral/genética; Degeneración del Disco Intervertebral/metabolismo; Subunidad alfa 1 del Factor de Unión al Sitio Principal/metabolismo; Coactivador 1 de Receptor Nuclear; Ratones Endogámicos C57BL; Matriz Extracelular/metabolismo; Metaloproteasas/metabolismo; Disco Intervertebral/metabolismo

Palabras clave

HECT and RLD domain containing E3 ubiquitin-protein ligase 3; Histone acetyltransferase p300; Intervertebral disc degeneration; Matrix metallopeptidases; Nuclear receptor coactivator 1; Runt-related transcription factor 2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Degeneración del Disco Intervertebral / Disco Intervertebral Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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