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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan; Skok, Ziga; Szili, Petra Eva; Czikkely, Márton; Maharramov, Elvin; Vu, Thu Hien; Piras, Maria Vittoria; Zidar, Nace; Ilas, Janez; Zega, Anamarija; Trontelj, Jurij; Pardo, Luis A; Hughes, Diarmaid; Huseby, Douglas; Berruga-Fernández, Tália; Cao, Sha; Simoff, Ivailo; Svensson, Richard; Korol, Sergiy V; Jin, Zhe; Vicente, Francisca; Ramos, Maria C; Mundy, Julia E A; Maxwell, Anthony; Stevenson, Clare E M; Lawson, David M; Glinghammar, Björn; Sjöström, Eva; Bohlin, Martin; Oreskär, Joanna; Alvér, Sofie; Janssen, Guido V; Sterk, Geert Jan; Kikelj, Danijel; Pal, Csaba; Tomasic, Tihomir; Peterlin Masic, Lucija.
Afiliación
  • Durcik M; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Cotman AE; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Toplak Z; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Mozina S; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Skok Z; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Szili PE; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary.
  • Czikkely M; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary.
  • Maharramov E; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary.
  • Vu TH; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary.
  • Piras MV; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Zidar N; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Ilas J; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Zega A; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Trontelj J; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Pardo LA; Max Planck Institute for Multidisciplinary Sciences, Oncophysiology, Hermann-Rein-Str. 3, Göttingen 37075, Germany.
  • Hughes D; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Huseby D; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Berruga-Fernández T; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Cao S; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Simoff I; Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) Department of Pharmacy, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Svensson R; Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) Department of Pharmacy, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Korol SV; Department of Medical Cell Biology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Jin Z; Department of Medical Cell Biology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden.
  • Vicente F; Fundación Medina, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, Granada 18016, Spain.
  • Ramos MC; Fundación Medina, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, Granada 18016, Spain.
  • Mundy JEA; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
  • Maxwell A; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
  • Stevenson CEM; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
  • Lawson DM; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
  • Glinghammar B; Department of Chemical and Pharmaceutical Toxicology, RISE Research Institutes of Sweden, Södertälje 15136, Sweden.
  • Sjöström E; Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden.
  • Bohlin M; Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden.
  • Oreskär J; Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden.
  • Alvér S; Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden.
  • Janssen GV; Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands.
  • Sterk GJ; Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands.
  • Kikelj D; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Pal C; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary.
  • Tomasic T; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
  • Peterlin Masic L; Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana 1000, Slovenia.
J Med Chem ; 66(6): 3968-3994, 2023 03 23.
Article en En | MEDLINE | ID: mdl-36877255
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Staphylococcus aureus Resistente a Vancomicina Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Staphylococcus aureus Resistente a Vancomicina Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Estados Unidos