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Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism.
Ichikawa, Shunsuke; Abe, Reimi; Fujimoto, Haruka; Higashi, Koushi; Zang, Liqing; Nakayama, Hiroko; Matsuoka, Izumi; Shimada, Yasuhito.
Afiliación
  • Ichikawa S; Faculty of Education, Mie University, Tsu, Mie, Japan.
  • Abe R; Mie University Zebrafish Drug Screening Center, Tsu, Japan.
  • Fujimoto H; Faculty of Education, Mie University, Tsu, Mie, Japan.
  • Higashi K; Faculty of Education, Mie University, Tsu, Mie, Japan.
  • Zang L; Faculty of Education, Mie University, Tsu, Mie, Japan.
  • Nakayama H; Mie University Zebrafish Drug Screening Center, Tsu, Japan.
  • Matsuoka I; Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie, Japan.
  • Shimada Y; Mie University Zebrafish Drug Screening Center, Tsu, Japan.
Front Microbiol ; 14: 1079187, 2023.
Article en En | MEDLINE | ID: mdl-36876090
Interventions to the gut microbiome manipulate the gut-brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium Paraburkholderia sabiae reduces anxiety-like behavior in adult zebrafish. P. sabiae administration increased the diversity of the zebrafish gut microbiome. Linear discriminant analysis Effect Size (LEfSe) analysis revealed that the populations of Actinomycetales including Nocardiaceae, Nocardia, Gordoniaceae, Gordonia, Nakamurellaceae, and Aeromonadaceae were reduced, whereas those of Rhizobiales including Xanthobacteraceae, Bradyrhizobiaceae, Rhodospirillaceae, and Pirellulaceae were increased in the gut microbiome. Functional analysis using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2) predicted that P. sabiae administration altered taurine metabolism in the zebrafish gut, and we demonstrated that P. sabiae administration increased the taurine concentration in the brain. Since taurine functions as an antidepressant neurotransmitter in vertebrates, our results suggest that P. sabiae could improve anxiety-like behavior in zebrafish via the gut-brain axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza