Your browser doesn't support javascript.
loading
Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model.
Stevens, Christian S; Lowry, Jake; Juelich, Terry; Atkins, Colm; Johnson, Kendra; Smith, Jennifer K; Panis, Maryline; Ikegami, Tetsuro; tenOever, Benjamin; Freiberg, Alexander N; Lee, Benhur.
Afiliación
  • Stevens CS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Lowry J; Animal Resource Center, University of Texas Medical Branch, Galveston, Texas, USA.
  • Juelich T; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Atkins C; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Johnson K; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Smith JK; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Panis M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Ikegami T; Department of Microbiology, New York University, New York, New YorkUSA.
  • tenOever B; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Freiberg AN; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Lee B; Department of Microbiology, New York University, New York, New YorkUSA.
J Infect Dis ; 228(5): 604-614, 2023 08 31.
Article en En | MEDLINE | ID: mdl-36869692
The common marmoset (Callithrix jacchus) is increasingly recognized as an ideal nonhuman primate (NHP) at high biocontainment due to its smaller size and relative ease of handling. Here, we evaluated the susceptibility and pathogenesis of Nipah virus Bangladesh strain (NiVB) infection in marmosets at biosafety level 4. Infection via the intranasal and intratracheal route resulted in fatal disease in all 4 infected marmosets. Three developed pulmonary edema and hemorrhage as well as multifocal hemorrhagic lymphadenopathy, while 1 recapitulated neurologic clinical manifestations and cardiomyopathy on gross pathology. Organ-specific innate and inflammatory responses were characterized by RNA sequencing in 6 different tissues from infected and control marmosets. Notably, a unique transcriptome was revealed in the brainstem of the marmoset exhibiting neurological signs. Our results provide a more comprehensive understanding of NiV pathogenesis in an accessible and novel NHP model, closely reflecting clinical disease as observed in NiV patients.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Pulmonar / Virus Nipah / Infecciones por Henipavirus Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Pulmonar / Virus Nipah / Infecciones por Henipavirus Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos