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Oligomer nanoparticle release from polylactic acid plastics catalysed by gut enzymes triggers acute inflammation.
Wang, Mengjing; Li, Qianqian; Shi, Changzhi; Lv, Jia; Xu, Youdong; Yang, Junjie; Chua, Shae Linn; Jia, Linran; Chen, Huaiwen; Liu, Qian; Huang, Changjin; Huang, Yichao; Chen, Jianmin; Fang, Mingliang.
Afiliación
  • Wang M; Department of Environmental Science and Engineering, Fudan University, Shanghai, China.
  • Li Q; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, Singapore.
  • Shi C; Key Laboratory of Environmental Nanotechnology and Health Effects, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  • Lv J; Department of Environmental Science and Engineering, Fudan University, Shanghai, China.
  • Xu Y; Department of Toxicology, School of Public Health; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China.
  • Yang J; State Key Laboratory of Proteomics, National Center for Protein Sciences-Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
  • Chua SL; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, Singapore.
  • Jia L; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
  • Chen H; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, Singapore.
  • Liu Q; Sunlipo Biotech Research Center for Nanomedicine, Shanghai, China.
  • Huang C; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  • Huang Y; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.
  • Chen J; Department of Toxicology, School of Public Health; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China. yichao.huang@ahmu.edu.cn.
  • Fang M; Department of Environmental Science and Engineering, Fudan University, Shanghai, China. jmchen@fudan.edu.cn.
Nat Nanotechnol ; 18(4): 403-411, 2023 04.
Article en En | MEDLINE | ID: mdl-36864128
The health risks of exposure to 'eco-friendly' biodegradable plastics of anthropogenic origin and their effects on the gastrointestinal tract are largely unknown. Here we demonstrate that the enzymatic hydrolysis of polylactic acid microplastics generated nanoplastic particles by competing for triglyceride-degrading lipase during gastrointestinal processes. Nanoparticle oligomers were formed by hydrophobically driven self-aggregation. In a mouse model, polylactic acid oligomers and their nanoparticles bioaccumulated in the liver, intestine and brain. Hydrolysed oligomers caused intestinal damage and acute inflammation. A large-scale pharmacophore model revealed that oligomers interacted with matrix metallopeptidase 12. Mechanistically, high binding affinity (Kd = 13.3 µmol l-1) of oligomers to the catalytic zinc-ion finger domain led to matrix metallopeptidase 12 inactivation, which might mediate the adverse bowel inflammatory effects after exposure to polylactic acid oligomers. Biodegradable plastics are considered to be a solution to address environmental plastic pollution. Thus, understanding the gastrointestinal fates and toxicities of bioplastics will provide insights into potential health risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásticos Biodegradables Límite: Animals Idioma: En Revista: Nat Nanotechnol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásticos Biodegradables Límite: Animals Idioma: En Revista: Nat Nanotechnol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido