[Update on the role and mechanism of erythropoietin receptor in acute kidney injury and repair or fibrosis].
Sheng Li Xue Bao
; 75(1): 115-129, 2023 Feb 25.
Article
en Zh
| MEDLINE
| ID: mdl-36859841
Acute kidney injury (AKI) is a common critical disease clinically with high morbility and mortality and some survival patients also progress to chronic kidney disease. Renal ischemia-reperfusion (IR) is one of the main causes of AKI, in which, its repair and potential fibrosis, apoptosis, inflammation and phagocytosis play important roles. During the progression of IR-induced AKI, the expression of erythropoietin homodimer receptor (EPOR)2 and EPOR and ß common receptor formed heterodimer receptor (EPOR/ßcR) is changed dynamically. Moreover, (EPOR)2 and EPOR/ßcR may synergistically participate in renoprotection at the stage of AKI and early repair, whereas at the late stage of AKI, the (EPOR)2 induces renal fibrosis and the EPOR/ßcR facilitates repair and remodelling. The underlying mechanism, signaling pathways and the different effect turning point of (EPOR)2 and EPOR/ßcR have not been well defined. It has been reported that EPO, according to its 3D structure, derived helix B surface peptide (HBSP) and cyclic HBSP (CHBP) only bind to EPOR/ßcR. Synthesized HBSP, therefore, provides an effective tool to distinguish the different roles and mechanisms of both receptors, with the (EPOR)2 promoting fibrosis or the EPOR/ßcR leading to repair/remodelling at the late stage of AKI. This review discusses the similarities and differences of (EPOR)2 and EPOR/ßcR in their impacts on apoptosis, inflammation and phagocytosis in AKI, repair and fibrosis post IR, associated mechanisms, signaling pathways and outcomes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Lesión Renal Aguda
Límite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2023
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China