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Molar-mass-dependent antibacterial activity of cationic dextran derivatives against resistant nosocomial pathogens.
Vrzonová, Romana; Cízová, Alzbeta; Racková, Lucia; Mecárová, Jana; Bieliková, Sandra; Bystrický, Slavomír.
Afiliación
  • Vrzonová R; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. Electronic address: romana.vrzonova@savba.sk.
  • Cízová A; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. Electronic address: alzbeta.cizova@savba.sk.
  • Racková L; Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia. Electronic address: lucia.rackova@savba.sk.
  • Mecárová J; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. Electronic address: valarikova.jana@savba.sk.
  • Bieliková S; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. Electronic address: sandra.bielikova@savba.sk.
  • Bystrický S; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia. Electronic address: slavomir.bystricky@savba.sk.
Int J Biol Macromol ; 235: 123854, 2023 Apr 30.
Article en En | MEDLINE | ID: mdl-36858094
The rise of various multidrug-resistant bacteria has created a need for new biocompatible and biodegradable antibacterial compounds. Cationic polysaccharides are promising candidates for this role. Therefore, cationic derivatives of commercial dextrans with molar masses of 11 kDa, 76 kDa, 411 kDa, and 1500-2500 kDa and various degrees of substitution (DSQ 0.34-0.52) were prepared and their antimicrobial properties against four gram-negative nosocomial bacteria were tested. As expected, a higher DSQ led to higher efficiency. The best antimicrobial properties were found for derivatives of 411 kDa, followed by 76 kDa and 1500-2000 kDa dextrans. This indicates that there is a certain optimum molar mass with the best antimicrobial properties. However, as molar mass increased, the biocompatibility of cationic dextran steadily decreased, with increased hemagglutination and toxicity being seen for human cells. The derivatives of 76 kDa dextran with higher DSQ (0.40-0.52) were the best antimicrobial agents suitable for further clinical testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infección Hospitalaria / Antiinfecciosos Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infección Hospitalaria / Antiinfecciosos Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos