Organophotoredox-mediated Formal [3+2]-Cycloaddition of 2H-Azirines with Aryldiazonium Salts: Direct Access to Trisubstituted 1,2,4-Triazoles.

Mishra, Poornima; Kumar, Prashant; Srivastava, Oj Shikhar; Rastogi, Namrata

Mishra, Poornima; Kumar, Prashant; Srivastava, Oj Shikhar; Rastogi, Namrata.

Afiliación

Mishra P; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sec. 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India.
Kumar P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Srivastava OS; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sec. 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India.
Rastogi N; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sec. 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226031, India.

Chem Asian J ; 18(7): e202300007, 2023 Apr 03.

Article en En | MEDLINE | ID: mdl-36852773

RESUMEN

The present work documents an organophotoredox-mediated formal [3+2]-cycloaddition of 2H-azirines with aryl diazonium tetrafluoroborate salts to furnish 1,3,5-trisubstituted 1,2,4-triazoles. The reaction furnishes a regioisomeric mixture of 1,2,4-triazoles in case of unsymmetrically substituted azirines. It is noteworthy that aryl radical generation from diazonium salt under visible light photoredox conditions could be successfully avoided by carefully selecting the reaction conditions.

Palabras clave

1,2,4-triazoles; 2H-azirines Organophotocatalytic; aryldiazonium salts; cycloaddition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Asian J Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania

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