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Cocaine-use disorder and childhood maltreatment are associated with the activation of neutrophils and increased inflammation.
Funchal, Giselle A; Schuch, Jaqueline B; Zaparte, Aline; Sanvicente-Vieira, Breno; Viola, Thiago W; Grassi-Oliveira, Rodrigo; Bauer, Moisés E.
Afiliación
  • Funchal GA; Laboratory of Immunobiology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Schuch JB; Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Zaparte A; Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Sanvicente-Vieira B; LSU Health New Orleans School of Medicine, Pulmonary/Critical Care & Allergy/Immunology, New Orleans, LA, USA.
  • Viola TW; Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Grassi-Oliveira R; Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Bauer ME; Developmental Cognitive Neuroscience Lab, School of Medicine, Brain Institute of the Rio Grande do Sul (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Acta Neuropsychiatr ; 36(2): 97-108, 2024 Apr.
Article en En | MEDLINE | ID: mdl-36847141
BACKGROUND: Cocaine-use disorder (CUD) has been associated with early life adversity and activated cellular immune responses. Women are most vulnerable to complications from chronic substance disorders, generally presenting an intense feeling of abstinence and consuming significant drug amounts. Here, we investigated neutrophil functional activities in CUD, including the formation of neutrophil extracellular traps (NETs) and related intracellular signalling. We also investigated the role of early life stress in inflammatory profiles. METHODS: Blood samples, clinical data, and history of childhood abuse or neglect were collected at the onset of detoxification treatment of 41 female individuals with CUD and 31 healthy controls (HCs). Plasma cytokines, neutrophil phagocytosis, NETs, intracellular reactive oxygen species (ROS) generation, and phosphorylated protein kinase B (Akt) and mitogen-activated protein kinases (MAPK)s were assessed by flow cytometry. RESULTS: CUD subjects had higher scores of childhood trauma than controls. Increased plasma cytokines (TNF-α, IL-1ß, IL-6, IL-8, IL-12, and IL-10), neutrophil phagocytosis, and production of NETs were reported in CUD subjects as compared to HC. Neutrophils of CUD subjects also produced high levels of intracellular ROS and had more activated Akt and MAPKs (p38/ERK), which are essential signalling pathways involved in cell survival and NETs production. Childhood trauma scores were significantly associated with neutrophil activation and peripheral inflammation. CONCLUSION: Our study reinforces that smoked cocaine and early life stress activate neutrophils in an inflammatory environment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Maltrato a los Niños / Cocaína / Trastornos Relacionados con Sustancias Tipo de estudio: Risk_factors_studies Límite: Child / Female / Humans Idioma: En Revista: Acta Neuropsychiatr Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Maltrato a los Niños / Cocaína / Trastornos Relacionados con Sustancias Tipo de estudio: Risk_factors_studies Límite: Child / Female / Humans Idioma: En Revista: Acta Neuropsychiatr Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido