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(8-Hydroxyquinoline) Gallium(III) Complex with High Antineoplastic Efficacy for Treating Colon Cancer via Multiple Mechanisms.
Zhou, Si-Han; Liao, Wen-Hui; Yang, Yun; Li, Wei; Wu, Yuan-Yuan; Wu, Tian-Tian; Deng, Shi-Hui; Zhou, Jie; Li, Zhe; Zhao, Qi-Hua; Xu, Jing-Yuan; Chen, Ceshi; Xie, Ming-Jin.
Afiliación
  • Zhou SH; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Liao WH; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Yang Y; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Li W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.
  • Wu YY; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Wu TT; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Deng SH; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Zhou J; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Li Z; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
  • Zhao QH; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  • Xu JY; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
  • Chen C; The Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China.
  • Xie MJ; School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
ACS Omega ; 8(7): 6945-6958, 2023 Feb 21.
Article en En | MEDLINE | ID: mdl-36844596
A series of (8-hydroxyquinoline) gallium(III) complexes (CP-1-4) was synthesized and characterized by single X-ray crystallography and density functional theory (DFT) calculation. The cytotoxicity of the four gallium complexes toward a human nonsmall cell lung cancer cell line (A549), human colon cancer cell line (HCT116), and human normal hepatocyte cell line (LO2) was evaluated using MTT assays. CP-4 exhibited excellent cytotoxicity against HCT116 cancer cells (IC50 = 1.2 ± 0.3 µM) and lower toxicity than cisplatin and oxaliplatin. We also evaluated the anticancer mechanism studies in cell uptake, reactive oxygen species analysis, cell cycle, wound-healing, and Western blotting assays. The results showed that CP-4 affected the expression of DNA-related proteins, which led to the apoptosis of cancer cells. Moreover, molecular docking tests of CP-4 were performed to predict other binding sites and to confirm its higher binding force to disulfide isomerase (PDI) proteins. The emissive properties of CP-4 suggest that this complex can be used for colon cancer diagnosis and treatment, as well as in vivo imaging. These results also provide a foundation for the development of gallium complexes as potent anticancer agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos