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Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application.
Deaconu, Mihaela; Prelipcean, Ana-Maria; Brezoiu, Ana-Maria; Mitran, Raul-Augustin; Isopencu, Gabriela; Matei, Cristian; Berger, Daniela.
Afiliación
  • Deaconu M; CAMPUS Research Institute, University "Politehnica" of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
  • Prelipcean AM; Faculty of Chemical Engineering and Biotechnologies, University "Politehnica" of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
  • Brezoiu AM; National Institute of R&D for Biological Sciences, 296 Splaiul Independetei, 060031 Bucharest, Romania.
  • Mitran RA; Faculty of Chemical Engineering and Biotechnologies, University "Politehnica" of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
  • Isopencu G; "Ilie Murgulescu" Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania.
  • Matei C; Faculty of Chemical Engineering and Biotechnologies, University "Politehnica" of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
  • Berger D; Faculty of Chemical Engineering and Biotechnologies, University "Politehnica" of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
Pharmaceutics ; 15(2)2023 Jan 17.
Article en En | MEDLINE | ID: mdl-36839635
Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell regeneration using natural components. A polyphenolic extract obtained from Salvia officinalis was embedded in functionalized mesoporous silica nanoparticles for better stability, followed by their distribution into a collagen porous scaffold. The resulting polyphenols-loaded MSN exhibited enhanced antibacterial activity and good cytocompatibility. Improved thermal stability of the collagen porous scaffold was obtained due to the presence of the functionalized MSN. For the first time, collagen-polyphenols-loaded silica composites were reported in the literature as potential wound dressings. The newly developed composites showed excellent sterility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza