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Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features.
Khashchenko, Elena P; Uvarova, Elena V; Fatkhudinov, Timur Kh; Chuprynin, Vladimir D; Asaturova, Aleksandra V; Kulabukhova, Elena A; Vysokikh, Mikhail Yu; Allakhverdieva, Elvina Z; Alekseeva, Maria N; Adamyan, Leila V; Sukhikh, Gennady T.
Afiliación
  • Khashchenko EP; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Uvarova EV; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Fatkhudinov TK; Department for Obstetrics, Gynecology, Perinatology and Reproduction, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Bld. 2, 119991 Moscow, Russia.
  • Chuprynin VD; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Asaturova AV; Department of Histology, Cytology and Embryology, Peoples' Friendship University of Russia (RUDN University), 117997 Moscow, Russia.
  • Kulabukhova EA; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Vysokikh MY; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Allakhverdieva EZ; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Alekseeva MN; FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov" Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia.
  • Adamyan LV; A.N. Belozersky Research Institute of Physico-Chemical Biology MSU, Leninskye Gory, House 1, Building 40, 119992 Moscow, Russia.
  • Sukhikh GT; Faculty of Fundamental Medicine, Moscow State University Named after M.V. Lomonosov, 119991 Moscow, Russia.
J Clin Med ; 12(4)2023 Feb 20.
Article en En | MEDLINE | ID: mdl-36836214
BACKGROUND: The early diagnosis of endometriosis in adolescents is not developed. OBJECTIVE: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. METHODS: In total, 134 girls (from menarche to 17 years old) were included in a case-control study: 90 with laparoscopically (LS) confirmed PE, 44 healthy controls underwent full examination and LS was analyzed in the PE group. RESULTS: Patients with PE were characterized with heredity for endometriosis, persistent dysmenorrhea, decreased daily activity, gastrointestinal symptoms, higher LH, estradiol, prolactin and Ca-125 (<0.05 for each). Ultrasound detected PE in 3.3% and MRI in 78.9%. The most essential MRI signs are as follows: hypointense foci, the heterogeneity of the pelvic tissue (paraovarian, parametrial and rectouterine pouch) and sacro-uterine ligaments lesions (<0.05 for each). Adolescents with PE mostly exhibit initial rASRM stages. Red implants correlated with the rASRM score, and sheer implants correlated with pain (VAS score) (<0.05). In 32.2%, foci consisted of fibrous, adipose and muscle tissue; black lesions were more likely to be histologically verified (0.001). CONCLUSION: Adolescents exhibit mostly initial PE stages, which are associated with greater pain. Persistent dysmenorrhea and detected MRI parameters predict the laparoscopic confirmation of initial PE in adolescents in 84.3% (OR 15.4; <0.01), justifying the early surgical diagnostics and shortening the time delay and suffering of the young patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza