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The Pleiotropic Role of Vitamin K in Multimorbidity of Chronic Obstructive Pulmonary Disease.
Piscaer, Ianthe; Janssen, Rob; Franssen, Frits M E; Schurgers, Leon J; Wouters, Emiel F M.
Afiliación
  • Piscaer I; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), 6200 MD Maastricht, The Netherlands.
  • Janssen R; Department of Respiratory Medicine, Canisius-Wilhelmina Hospital, 6532 SZ Nijmegen, The Netherlands.
  • Franssen FME; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), 6200 MD Maastricht, The Netherlands.
  • Schurgers LJ; Department of Research and Development, CIRO+, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands.
  • Wouters EFM; Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200 MD Maastricht, The Netherlands.
J Clin Med ; 12(4)2023 Feb 05.
Article en En | MEDLINE | ID: mdl-36835797
Although defined by the presence of airflow obstruction and respiratory symptoms, patients with chronic obstructive pulmonary disease (COPD) are characterized by multimorbidity. Numerous co-occurring conditions and systemic manifestations contribute to the clinical presentation and progression of COPD; however, underlying mechanisms for multimorbidity are currently not fully elucidated. Vitamin A and vitamin D have been related to COPD pathogenesis. Another fat-soluble vitamin, vitamin K, has been put forward to exert protective roles in COPD. Vitamin K is an unequivocal cofactor for the carboxylation of coagulation factors, but also for extra-hepatic proteins including the soft tissue calcification inhibitor matrix Gla-protein and the bone protein osteocalcin. Additionally, vitamin K has been shown to have anti-oxidant and anti-ferroptosis properties. In this review, we discuss the potential role of vitamin K in the systemic manifestations of COPD. We will elaborate on the effect of vitamin K on prevalent co-occurring chronic conditions in COPD including cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Finally, we link these conditions to COPD with vitamin K as a connecting factor and provide recommendations for future clinical studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza