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Adverse Human Health Effects of Chromium by Exposure Route: A Comprehensive Review Based on Toxicogenomic Approach.
Shin, Dong Yeop; Lee, Sang Min; Jang, Yujin; Lee, Jun; Lee, Cheol Min; Cho, Eun-Min; Seo, Young Rok.
Afiliación
  • Shin DY; Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea.
  • Lee SM; Insilicogen Inc., Suwon 441813, Republic of Korea.
  • Jang Y; Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea.
  • Lee J; Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea.
  • Lee CM; Department of Nano, Chemical & Biological Engineering, College of Natural Science and Engineering, Seokyeong University, Seoul 02173, Republic of Korea.
  • Cho EM; Department of Nano, Chemical & Biological Engineering, College of Natural Science and Engineering, Seokyeong University, Seoul 02173, Republic of Korea.
  • Seo YR; Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea.
Int J Mol Sci ; 24(4)2023 Feb 08.
Article en En | MEDLINE | ID: mdl-36834821
Heavy metals are defined as metals with relatively high density and atomic weight, and their various applications have raised serious concerns about the environmental impacts and potential human health effects. Chromium is an important heavy metal that is involved in biological metabolism, but Cr exposure can induce a severe impact on occupational workers or public health. In this study, we explore the toxic effects of Cr exposure through three exposure routes: dermal contact, inhalation, and ingestion. We propose the underlying toxicity mechanisms of Cr exposure based on transcriptomic data and various bioinformatic tools. Our study provides a comprehensive understanding of the toxicity mechanisms of different Cr exposure routes by diverse bioinformatics analyses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromo / Metales Pesados Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromo / Metales Pesados Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza