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The Value of Tucatinib in Metastatic HER2-Positive Breast Cancer Patients: An Italian Cost-Effectiveness Analysis.
Antonazzo, Ippazio Cosimo; Cortesi, Paolo Angelo; Miceli Sopo, Gerardo; Mazzaglia, Giampiero; Conte, Pierfranco; Mantovani, Lorenzo Giovanni.
Afiliación
  • Antonazzo IC; Research Centre on Public Health, University of Milan-Bicocca, 20900 Monza, Italy.
  • Cortesi PA; Research Centre on Public Health, University of Milan-Bicocca, 20900 Monza, Italy.
  • Miceli Sopo G; UOC Farmacia Ospedaliera OP-Continuità Ospedale Territorio e Distribuzione Diretta, ASL Roma 2, Roma Ospedaliera OP-Continuità Ospedale Territorio e Distribuzione, 00157 Ariccia, Italy.
  • Mazzaglia G; Research Centre on Public Health, University of Milan-Bicocca, 20900 Monza, Italy.
  • Conte P; San Camillo Hospital, IRCCS, Venezia Lido, 30126 Venice, Italy.
  • Mantovani LG; Research Centre on Public Health, University of Milan-Bicocca, 20900 Monza, Italy.
Cancers (Basel) ; 15(4)2023 Feb 12.
Article en En | MEDLINE | ID: mdl-36831518
BACKGROUND: This study was aimed at estimating the appropriate price of tucatinib plus trastuzumab and capecitabine (TXC), as third-line treatment, in HER2+ breast cancer (BC) patients from the Italian National Health System (NHS) perspective. METHODS: A partitioned survival model with three mutually exclusive health states (i.e., progression-free survival (PFS), progressive disease (PD), and death) was used to estimate the price of tucatinib vs trastuzumab emtansine (TDM-1), considering a willingness to pay (WTP) of 60,000 EUR. Data from the HER2CLIMB trial, the Italian population, and the literature were used as input. The model also estimated the total costs and the life-years (LY) of TXC and TDM1. Deterministic and probabilistic (PSA) sensitivity analyses were conducted to evaluate the robustness of the model. RESULTS: In the base case scenario, the appropriate price of tucatinib was 4828.44 EUR per cycle. The TXC resulted in +0.28 LYs and +16,628 EUR compared with TDM-1. Results were mainly sensitive to therapy intensity variation. In PSA analysis, TXC resulted cost-effective in 53% of the simulations. Assuming a WTP ranging 20,000-80,000 EUR, the tucatinib price ranged from 4090.60 to 5197.41 EUR. CONCLUSIONS: This study estimated the appropriate price for tucatinib according to different WTP in order to help healthcare decision makers to better understand the treatment value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Health_economic_evaluation / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza