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Malaria-driven adaptation of MHC class I in wild bonobo populations.
Wroblewski, Emily E; Guethlein, Lisbeth A; Anderson, Aaron G; Liu, Weimin; Li, Yingying; Heisel, Sara E; Connell, Andrew Jesse; Ndjango, Jean-Bosco N; Bertolani, Paco; Hart, John A; Hart, Terese B; Sanz, Crickette M; Morgan, David B; Peeters, Martine; Sharp, Paul M; Hahn, Beatrice H; Parham, Peter.
Afiliación
  • Wroblewski EE; Department of Anthropology, Washington University in St. Louis, Saint Louis, 63130, MO, USA. emily.wroblewski@wustl.edu.
  • Guethlein LA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Anderson AG; Department of Anthropology, Washington University in St. Louis, Saint Louis, 63130, MO, USA.
  • Liu W; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Li Y; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Heisel SE; Department of Anthropology, Washington University in St. Louis, Saint Louis, 63130, MO, USA.
  • Connell AJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Ndjango JN; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Bertolani P; Department of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani, BP 2012, Kisangani, Democratic Republic of the Congo.
  • Hart JA; Institute of Human Sciences, School of Anthropology and Museum Ethnography, University of Oxford, Oxford, UK.
  • Hart TB; Frankfurt Zoological Society, Lomami National Park Project, Kinshasa, Democratic Republic of the Congo.
  • Sanz CM; Frankfurt Zoological Society, Lomami National Park Project, Kinshasa, Democratic Republic of the Congo.
  • Morgan DB; Department of Anthropology, Washington University in St. Louis, Saint Louis, 63130, MO, USA.
  • Peeters M; Congo Program, Wildlife Conservation Society, Brazzaville, Republic of the Congo.
  • Sharp PM; Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, Chicago, IL, 60614, USA.
  • Hahn BH; Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34090, Montpellier, France.
  • Parham P; Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, EH9 3FL, UK.
Nat Commun ; 14(1): 1033, 2023 02 23.
Article en En | MEDLINE | ID: mdl-36823144
The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lymphocytes, confers protection against severe malaria. Gorilla, chimpanzee, and bonobo are humans' closest living relatives. These African apes have HLA-B orthologs and are infected by parasites in the same subgenus (Laverania) as P. falciparum, but the consequences of these infections are unclear. Laverania parasites infect bonobos (Pan paniscus) at only one (TL2) of many sites sampled across their range. TL2 spans the Lomami River and has genetically divergent subpopulations of bonobos on each side. Papa-B, the bonobo ortholog of HLA-B, includes variants having a B*53-like (B07) peptide-binding supertype profile. Here we show that B07 Papa-B occur at high frequency in TL2 bonobos and that malaria appears to have independently selected for different B07 alleles in the two subpopulations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Antígenos de Histocompatibilidad Clase I / Malaria Falciparum / Pan paniscus Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Antígenos de Histocompatibilidad Clase I / Malaria Falciparum / Pan paniscus Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido