Your browser doesn't support javascript.
loading
DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.
Seto-Tetsuo, Fumi; Arioka, Masaki; Miura, Koichi; Inoue, Takeru; Igawa, Kazunobu; Tomooka, Katsuhiko; Sasaguri, Toshiyuki.
Afiliación
  • Seto-Tetsuo F; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Microbiology and Oral Infection, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki, Japan. Electronic address: fumi22.t.pby.12.27@gmail.com.
  • Arioka M; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. Electronic address: arioka@med.uoeh-u.ac.jp.
  • Miura K; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: miura.koichi.468@m.kyushu-u.ac.jp.
  • Inoue T; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: moeyo9dragons11@gmail.com.
  • Igawa K; Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan. Electronic address: igawa@kumamoto-u.ac.jp.
  • Tomooka K; Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan. Electronic address: ktomooka@cm.kyushu-u.ac.jp.
  • Sasaguri T; Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: sasaguri.toshiyuki.922@m.kyushu-u.ac.jp.
Int Immunopharmacol ; 117: 109913, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36812674
The tumor microenvironment (TME), largely composed of tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), plays a key role in cancer progression. A small molecule, differentiation-inducing factor-1 (DIF-1) secreted by Dictyostelium discoideum, is known to exhibit anticancer activity; however, its effect on the TME remains unknown. In this study, we investigated the effect of DIF-1 on the TME using mouse triple-negative breast cancer 4T1-GFP cells, mouse macrophage RAW 264.7 cells, and mouse primary dermal fibroblasts (DFBs). Polarization of 4T1 cell-conditioned medium-induced macrophage into TAMs was not affected by DIF-1. In contrast, DIF-1 decreased 4T1 cell co-culturing-induced C-X-C motif chemokine ligand 1 (CXCL1), CXCL5, and CXCL7 expression in DFBs and suppressed DFB differentiation into CAF-like cells. Additionally, DIF-1 inhibited C-X-C motif chemokine receptor 2 (CXCR2) expression in 4T1 cells. Immunohistochemical analyses of tumor tissue samples excised from breast cancer-bearing mice showed that DIF-1 did not affect the number of CD206-positive TAMs; however, it decreased the number of α-smooth muscle actin-positive CAFs and CXCR2 expression. These results indicated that the anticancer effect of DIF-1 was partially attributed to the inhibition of CXCLs/CXCR2 axis-mediated communication between breast cancer cells and CAFs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dictyostelium / Fibroblastos Asociados al Cáncer / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dictyostelium / Fibroblastos Asociados al Cáncer / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos