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Accelerometer-measured physical activity and postmenopausal breast cancer incidence in the Women's Health Accelerometry Collaboration.
Hyde, Eric T; LaCroix, Andrea Z; Evenson, Kelly R; Howard, Annie Green; Anuskiewicz, Blake; Di, Chongzhi; Bellettiere, John; LaMonte, Michael J; Manson, JoAnn E; Buring, Julie E; Shiroma, Eric J; Lee, I-Min; Parada, Humberto.
Afiliación
  • Hyde ET; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California, USA.
  • LaCroix AZ; Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA.
  • Evenson KR; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California, USA.
  • Howard AG; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Anuskiewicz B; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Di C; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Bellettiere J; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California, USA.
  • LaMonte MJ; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
  • Manson JE; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California, USA.
  • Buring JE; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York, USA.
  • Shiroma EJ; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Lee IM; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Parada H; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Cancer ; 129(10): 1579-1590, 2023 05 15.
Article en En | MEDLINE | ID: mdl-36812131
BACKGROUND: Few studies have examined accelerometer-measured physical activity and incident breast cancer (BC). Thus, this study examined associations between accelerometer-measured vector magnitude counts per 15 seconds (VM/15s) and average daily minutes of light physical activity (LPA), moderate-to-vigorous PA (MVPA), and total PA (TPA) and BC risk among women in the Women's Health Accelerometry Collaboration (WHAC). METHODS: The WHAC comprised 21,089 postmenopausal women (15,375 from the Women's Health Study [WHS]; 5714 from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health Study [OPACH]). Women wore an ActiGraph GT3X+ on the hip for ≥4 days and were followed for 7.4 average years to identify physician-adjudicated in situ (n = 94) or invasive (n = 546) BCs. Multivariable stratified Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for tertiles of physical activity measures in association with incident BC overall and by cohort. Effect measure modification was examined by age, race/ethnicity, and body mass index (BMI). RESULTS: In covariate-adjusted models, the highest (vs. lowest) tertiles of VM/15s, TPA, LPA, and MVPA were associated with BC HRs of 0.80 (95% CI, 0.64-0.99), 0.84 (95% CI, 0.69-1.02), 0.89 (95% CI, 0.73-1.08), and 0.81 (95% CI, 0.64-1.01), respectively. Further adjustment for BMI or physical function attenuated these associations. Associations were more pronounced among OPACH than WHS women for VM/15s, MVPA, and TPA; younger than older women for MVPA; and women with BMI ≥30 than <30 kg/m2 for LPA. CONCLUSION: Greater levels of accelerometer-assessed PA were associated with lower BC risk. Associations varied by age and obesity and were not independent of BMI or physical function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans Idioma: En Revista: Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos